SMAD3
همساخت ۳ مادران مخالف دکپنتاپلجیک (انگلیسی: Mothers against decapentaplegic homolog 3) یک پروتئین است که در انسان توسط ژن «SMAD3» واقع بر بازوی بلند کروموزوم ۱۵ کُدگذاری میشود.[4][5]
این پروتئین عضوی از خانواده بزرگ SMAD است که این نیز به نوبهٔ خود، جزئی از اَبَرخانوادهٔ فاکتور رشد تغییردهنده بتا است.
نقش این پروتئین، تعدیل پیامهایی است که توسط فاکتور رشد تغییردهنده بتا آغاز میشود و در تزاید، تمایز و مرگ سلول نقش دارد.[6][7]
اهمیت بالینی
افزایش فعالیت SMAD3 در بیماریزایی اسکلرودرمی نقش دارد. مولکول SMAD3 همچنین یک تنظیمکنندهٔ چندکاره در فیزیولوژی چربی است و با بروز چاقی و دیابت نوع ۲ مرتبط است.
این پروتئین همچنین در سرطان پروستات،[8][9] سرطان روده بزرگ،[10][11][12] سرطان پستان[13] و فیبروز کلیهها[14] نقش دارد.
جستارهای وابسته
منابع
- GRCm38: Ensembl release 89: ENSMUSG00000032402 - Ensembl, May 2017
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- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: SMAD3 SMAD family member 3".
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- مشارکتکنندگان ویکیپدیا. «Mothers against decapentaplegic homolog 3». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۵ مارس ۲۰۲۰.
برای مطالعهٔ بیشتر
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