RFXANK

RFXANK
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UXG, 3V30, 4QQM
معین‌کننده‌ها
نام‌های دیگر	RFXANK, ANKRA1, BLS, F14150_1, RFX-B, regulatory factor X associated ankyrin containing protein
شناسه‌های بیرونی	OMIM: 603200 MGI: 1333865 HomoloGene: 2760 GeneCards: RFXANK
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[1]
End	70,139,154 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001104 transcription coregulator activity; • histone deacetylase binding;
ترکیبات سلولی	• هسته یاخته; • نوکلئوپلاسم; • intercellular bridge; • سیتوپلاسم; • سیتوزول;
فرایند زیستی	• regulation of transcription by RNA polymerase II; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • Ras protein signal transduction; • positive regulation of transcription by RNA polymerase II;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8625
	19727
	ENSG00000064490
	ENSMUSG00000036120
	O14593
	Q9Z205
	NM_001278728، NM_003721، NM_134440، XM_005260134، XM_005260135، XM_005260137، NM_001370233، NM_001370234، NM_001370235، NM_001370236، NM_001370237، NM_001370238 NM_001278727، NM_001278728، NM_003721، NM_134440، XM_005260134، XM_005260135، XM_005260137، NM_001370233، NM_001370234، NM_001370235، NM_001370236، NM_001370237، NM_001370238
	NM_011266 NM_001025589، NM_011266
	NP_001265657، NP_003712، NP_604389، XP_005260191، XP_005260192، XP_005260194، NP_001357162، NP_001357163، NP_001357164، NP_001357165، NP_001357166، NP_001357167 NP_001265656، NP_001265657، NP_003712، NP_604389، XP_005260191، XP_005260192، XP_005260194، NP_001357162، NP_001357163، NP_001357164، NP_001357165، NP_001357166، NP_001357167
	NP_035396 NP_001020760، NP_035396
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین RFXANK متصل‌شونده به دی‌ان‌ای (انگلیسی: DNA-binding protein RFXANK‎) یک پروتئین است که در انسان توسط ژن «RFXANK» کُدگذاری می‌شود.[4][5][6]

این پروتئین در بیان ژن مجموعه سازگاری بافتی اصلی کلاس دو (MHC class II) نقش دارد که از اجزاء مهم دستگاه ایمنی بدن هستند.

دو نسخهٔ رونویسی متفاوت از این ژن شناسایی شده‌است که ایزوفرم‌های متفاوتی از پروتئین را کدگذاری می‌کنند که تنها یکی از این دو ایزوفرم، نقش «فعال‌کننده» دارند.[6]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000036120 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546.
Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.
"Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein".

مشارکت‌کنندگان ویکی‌پدیا. «RFXANK». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Lin JH, Makris A, McMahon C, Bear SE, Patriotis C, Prasad VR, Brent R, Golemis EA, Tsichlis PN (May 1999). "The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1". The Journal of Biological Chemistry. 274 (21): 14706–15. doi:10.1074/jbc.274.21.14706. PMID 10329666.
Nagarajan UM, Peijnenburg A, Gobin SJ, Boss JM, van den elsen PJ (Apr 2000). "Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells". Journal of Immunology. 164 (7): 3666–74. doi:10.4049/jimmunol.164.7.3666. PMID 10725724.
Wiszniewski W, Fondaneche MC, Lambert N, Masternak K, Picard C, Notarangelo L, Schwartz K, Bal J, Reith W, Alcaide C, de Saint Basile G, Fischer A, Lisowska-Grospierre B (Apr 2000). "Founder effect for a 26-bp deletion in the RFXANK gene in North African major histocompatibility complex class II-deficient patients belonging to complementation group B". Immunogenetics. 51 (4–5): 261–7. doi:10.1007/s002510050619. PMID 10803838.
Nekrep N, Jabrane-Ferrat N, Peterlin BM (Jun 2000). "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex". Molecular and Cellular Biology. 20 (12): 4455–61. doi:10.1128/MCB.20.12.4455-4461.2000. PMC 85813. PMID 10825209.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Nekrep N, Geyer M, Jabrane-Ferrat N, Peterlin BM (Aug 2001). "Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome". Molecular and Cellular Biology. 21 (16): 5566–76. doi:10.1128/MCB.21.16.5566-5576.2001. PMC 87278. PMID 11463838.
Dimberg J, Hugander A, Häll-Karlsson BM, Sirsjö A (Mar 2002). "RFX-B, a MHC class II transcription factor, suppressed in human colorectal adenocarcinomas". International Journal of Molecular Medicine. 9 (3): 213–6. doi:10.3892/ijmm.9.3.213. PMID 11836625.
Wiszniewski W, Fondaneche MC, Louise-Plence P, Prochnicka-Chalufour A, Selz F, Picard C, Le Deist F, Eliaou JF, Fischer A, Lisowska-Grospierre B (Feb 2003). "Novel mutations in the RFXANK gene: RFX complex containing in-vitro-generated RFXANK mutant binds the promoter without transactivating MHC II". Immunogenetics. 54 (11): 747–55. doi:10.1007/s00251-002-0521-1. PMID 12618906.
Wang AH, Grégoire S, Zika E, Xiao L, Li CS, Li H, Wright KL, Ting JP, Yang XJ (Aug 2005). "Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases". The Journal of Biological Chemistry. 280 (32): 29117–27. doi:10.1074/jbc.M500295200. PMID 15964851.
Krawczyk M, Masternak K, Zufferey M, Barras E, Reith W (Oct 2005). "New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study". Molecular and Cellular Biology. 25 (19): 8607–18. doi:10.1128/MCB.25.19.8607-8618.2005. PMC 1265745. PMID 16166641.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000036120 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806546-4] Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546.

[pmid10072068-5] Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.

[entrez-6] "Entrez Gene: RFXANK regulatory factor X-associated ankyrin-containing protein".