پی۵۳

پروتئین تومور پی۵۳
	بانک داده پروتئین : P53 کمپلکس همراه DNA[1]
Available structures
بانک داده پروتئین	Ortholog search: PDBe, RCSB
List of PDB id codes
	1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1JSP, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2F1X, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2OCJ, 2PCX, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR
شاخص‌ها
نماد ژن	TP53; BCC7; LFS1; P53; TRP53
External IDs	OMIM: 191170 MGI: 98834 HomoloGene: 460 ChEMBL: 4096 GeneCards: TP53 Gene
Gene Ontology
Molecular function	• RNA polymerase II core promoter sequence-specific DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; • RNA polymerase II transcription factor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; • protease binding; • p53 binding; • DNA binding; • chromatin binding; • damaged DNA binding; • sequence-specific DNA binding transcription factor activity; • copper ion binding; • protein binding; • ATP binding; • transcription factor binding; • zinc ion binding; • enzyme binding; • protein kinase binding; • protein phosphatase binding; • receptor tyrosine kinase binding; • ubiquitin protein ligase binding; • histone deacetylase regulator activity; • histone acetyltransferase binding; • identical protein binding; • transcription regulatory region DNA binding; • protein heterodimerization activity; • protein N-terminus binding; • chaperone binding; • protein phosphatase 2A binding; • MDM2/MDM4 family protein binding;
Cellular component	• chromatin; • nuclear chromatin; • nucleus; • nucleoplasm; • replication fork; • transcription factor TFIID complex; • nucleolus; • cytoplasm; • mitochondrion; • mitochondrial matrix; • endoplasmic reticulum; • cytosol; • nuclear matrix; • nuclear body; • PML body; • protein complex;
Biological process	• protein import into nucleus, translocation; • negative regulation of transcription from RNA polymerase II promoter; • DNA strand renaturation; • in utero embryonic development; • somitogenesis; • release of cytochrome c from mitochondria; • T cell proliferation involved in immune response; • B cell lineage commitment; • T cell lineage commitment; • response to ischemia; • base-excision repair; • nucleotide-excision repair; • double-strand break repair; • regulation of transcription, DNA-templated; • protein complex assembly; • apoptotic process; • cellular response to DNA damage stimulus; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • ER overload response; • cell cycle arrest; • transforming growth factor beta receptor signaling pathway; • Notch signaling pathway; • Ras protein signal transduction; • multicellular organismal development; • gastrulation; • negative regulation of neuroblast proliferation; • central nervous system development; • cell aging; • blood coagulation; • protein localization; • negative regulation of DNA replication; • cell proliferation; • negative regulation of cell proliferation; • determination of adult lifespan; • rRNA transcription; • response to salt stress; • response to X-ray; • response to gamma radiation; • positive regulation of cardiac muscle cell apoptotic process; • viral process; • cell differentiation; • negative regulation of cell growth; • DNA damage response, signal transduction by p53 class mediator; • negative regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of histone deacetylation; • chromatin assembly; • mitotic G1 DNA damage checkpoint; • positive regulation of protein oligomerization; • T cell differentiation in thymus; • regulation of tissue remodeling; • cellular protein localization; • cellular response to UV; • multicellular organism growth; • cellular response to drug; • cellular response to glucose starvation; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of apoptotic process; • positive regulation of apoptotic process; • negative regulation of apoptotic process; • positive regulation of neuron apoptotic process; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • response to antibiotic; • regulation of mitochondrial membrane permeability; • negative regulation of fibroblast proliferation; • embryonic organ development; • positive regulation of peptidyl-tyrosine phosphorylation; • negative regulation of helicase activity; • protein tetramerization; • neuron apoptotic process; • positive regulation of thymocyte apoptotic process; • positive regulation of cell cycle arrest; • cellular response to hypoxia; • cellular response to ionizing radiation; • mitotic cell cycle arrest; • intrinsic apoptotic signaling pathway by p53 class mediator; • positive regulation of release of cytochrome c from mitochondria; • positive regulation of cell aging; • replicative senescence; • oxidative stress-induced premature senescence; • intrinsic apoptotic signaling pathway; • oligodendrocyte apoptotic process; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • negative regulation of macromitophagy; • regulation of mitochondrial membrane permeability involved in apoptotic process; • negative regulation of reactive oxygen species metabolic process; • positive regulation of reactive oxygen species metabolic process; • positive regulation of intrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
اورتولوگ

ژن پی۵۳ (p۵۳) که همچنین پروتئین پی۵۳ نیز نامیده می‌شود، یک ژن سرکوبگر غده است که در انسان در ژن تی پی ۵۳ روی کروموزوم ۱۷ رمزگذاری شده‌است. این ژن در جانداران چند یاخته‌ای بسیار کارا می‌باشد زیرا در هماهنگی چرخهٔ یاخته‌ای و همچنین در جلوگیری از پدید آمدن سرطان بسیار کارگر می‌باشد.[2] ژن پی۵۳ «پاسدار ژنوم» خوانده شده‌است چون این ژن در نگهداشت پایایی ژنوم با جلوگیری از جهش در آن نقش دارد.[3]

نام پی۵۳ به وزن مولکولی آن بر می‌گردد که ۵۳ هزار دالتون پروتئین می‌باشد هر چند که بر پایهٔ برآوردها از روی ته نشست اسیدآمینهٔ آن، وزن مولکولی پی۵۳ تنها ۴۳٫۷ هزار دالتون است.[2]

این ژن کارکردهای ضدسرطان گوناگونی مانند نقش در آپوپتوز (مرگ برنامه‌ریزی شدهٔ یاخته)، پایایی ژنوم (بازدارندگی از پیدایش جهش در ژنوم)، و جلوگیری از رگ‌زایی دارد.[4]

P53 در تمایز سلولی نیز نقش دارد. مشاهده شده است که تنظیم سطح این پروتئین از طریق یوبی کوئیتیناسیون آن توسط آنزیم E3 لیگاز ویژه سلول های بنیادی بنام LIN41 یا TRIM71 و در نتیجه تخریب پروتئازومی آن که به کاهش بیان ژن‌های هدف مانند Puma و Noxa (فاکتورهای پرو آپوپتوزی) و Grhl3 (دخیل در تخصصی شدن و تمایز نهایی سلول‌های بنیادی) منجر می شود، برای بسته شدن صحیح لوله عصبی در دوران جنینی ضروری است.[5]

منابع

در ویکی‌انبار پرونده‌هایی دربارهٔ پی۵۳ موجود است.

Cho Y, Gorina S, Jeffrey PD, Pavletich NP (1994). "Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations". Science. 265 (5170): 346–55. doi:10.1126/science.8023157. PMID 8023157.
http://en.wikipedia.org/wiki/P53
Read, A. P. ; Strachan, T. (1999). "Chapter 18: Cancer Genetics". Human molecular genetics 2. New York: Wiley. ISBN 0-471-33061-2.
http://en.wikipedia.org/wiki/P53#Function
«The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation». Cell Death & Differentiation. 2017 Jun 1. doi:10.1038/cdd.2017.54. تاریخ وارد شده در |تاریخ= را بررسی کنید (کمک)

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[pmid8023157-1] Cho Y, Gorina S, Jeffrey PD, Pavletich NP (1994). "Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations". Science. 265 (5170): 346–55. doi:10.1126/science.8023157. PMID 8023157.

[en.wikipedia.org-2] ttp://en.wikipedia.org/wiki/P53

[3] Read, A. P. ; Strachan, T. (1999). "Chapter 18: Cancer Genetics". Human molecular genetics 2. New York: Wiley. ISBN 0-471-33061-2.

[4] ttp://en.wikipedia.org/wiki/P53#Function

[5] «The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation». Cell Death & Differentiation. 2017 Jun 1. doi:10.1038/cdd.2017.54. تاریخ وارد شده در |تاریخ= را بررسی کنید (کمک)