ZBTB16

ZBTB16
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BUO, 1CS3
معین‌کننده‌ها
نام‌های دیگر	ZBTB16, PLZF, ZNF145, zinc finger and BTB domain containing 16
شناسه‌های بیرونی	OMIM: 176797 MGI: 103222 HomoloGene: 21214 GeneCards: ZBTB16
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[1]
End	48,836,222 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • protein homodimerization activity; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • metal ion binding; • GO:0001078، GO:0001214، GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001948 پیوند پروتئینی; • identical protein binding; • nucleic acid binding; • double-stranded DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • protein C-terminus binding; • protein domain specific binding; • sequence-specific DNA binding;
ترکیبات سلولی	• PML body; • nuclear speck; • nuclear body; • پوسته یاخته; • transcription repressor complex; • هسته یاخته; • سیتوزول; • protein-containing complex; • نوکلئوپلاسم;
فرایند زیستی	• embryonic hindlimb morphogenesis; • forelimb morphogenesis; • skeletal system development; • myeloid cell differentiation; • regulation of transcription, DNA-templated; • embryonic pattern specification; • embryonic digit morphogenesis; • positive regulation of ossification; • negative regulation of transcription by RNA polymerase II; • hindlimb morphogenesis; • transcription, DNA-templated; • mesonephros development; • positive regulation of transcription, DNA-templated; • central nervous system development; • cartilage development; • male germ-line stem cell asymmetric division; • positive regulation of cartilage development; • protein ubiquitination; • positive regulation of chondrocyte differentiation; • positive regulation of apoptotic process; • protein localization to nucleus; • positive regulation of NK T cell differentiation; • negative regulation of transcription, DNA-templated; • positive regulation of fat cell differentiation; • negative regulation of myeloid cell differentiation; • anterior/posterior pattern specification; • negative regulation of cell population proliferation; • مرگ برنامه‌ریزی‌شده یاخته; • پیرایش پسارونویسی; • hemopoiesis; • positive regulation of transcription by RNA polymerase II;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7704
	235320
	ENSG00000109906
	ENSMUSG00000066687
	Q05516
	Q3UQ17
	NM_006006، XM_005271658، XM_017018259، XR_001747955، NM_001354750، NM_001354751، NM_001354752، XM_024448681 NM_001018011، NM_006006، XM_005271658، XM_017018259، XR_001747955، NM_001354750، NM_001354751، NM_001354752، XM_024448681
	NM_001364543 NM_001033324، NM_001364543
	NP_005997، XP_005271715، XP_016873748، NP_001341679، NP_001341680، NP_001341681، XP_024304449 NP_001018011، NP_005997، XP_005271715، XP_016873748، NP_001341679، NP_001341680، NP_001341681، XP_024304449
	NP_001351472، XP_036010785 NP_001028496، NP_001351472، XP_036010785
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین ۱۶ حاوی دومِـین BTB و انگشت روی (انگلیسی: Zinc finger and BTB domain-containing protein 16‎) یک پروتئین است که در انسان توسط ژن «ZBTB16» کُدگذاری می‌شود.

این ژن که بر روی کروموزوم ۱۱ واقع شده، یک فاکتور رونویسی دارای انگشت روی را کُدگذاری می‌کند و در پیشبرد چرخه سلول نقش دارد.

چندین نمونه از آرایش نابهنجار ژنی در جایگاه کروموزومی مذکور، در مبتلایان به لوسمی پرومیلوسیتیک حاد گزارش شده‌است.[4] همچنین چند نقش فیزیولوژیک برای این پروتئین در لنفوسیت‌های تی کشندهٔ طبیعی (NKT cells)[5][6] و در لنفوسیت‌های تی گاما دلتا (γδ T cells)[7] در موش‌ها یافت شده‌است. گونه‌های رونویسی متناوب از این ژن در انسان مشاهده شده‌است.[8][9]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000066687 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993). "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal. 12 (3): 1161–7. doi:10.1002/j.1460-2075.1993.tb05757.x. PMC 413318. PMID 8384553.
Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, et al. (2008). "The BTB-zinc finger transcriptional regulator, PLZF, controls the development of iNKT cell effector functions". Nature Immunology. 9 (9): 1055–64. doi:10.1038/ni.1641. PMC 2662733. PMID 18660811.
Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A (2008). "The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage". Immunity. 29 (3): 391–403. doi:10.1016/j.immuni.2008.07.011. PMC 2613001. PMID 18703361.
Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H (2009). "TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity". Proceedings of the National Academy of Sciences of the United States of America. 106 (30): 12453–8. doi:10.1073/pnas.0903895106. PMC 2718370. PMID 19617548.
Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, et al. (1999). "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11422–7. doi:10.1073/pnas.96.20.11422. PMC 18049. PMID 10500192.
"ZBTB16 zinc finger and BTB domain containing 16". Entrez. 4 October 2009. Retrieved 10 October 2009.

مشارکت‌کنندگان ویکی‌پدیا. «Zinc finger and BTB domain-containing protein 16». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر

Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993). "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal. 12 (3): 1161–7. doi:10.1002/j.1460-2075.1993.tb05757.x. PMC 413318. PMID 8384553.
Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derré J, Berger R, Waxman S, Chen Z (1993). "Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia". The Journal of Clinical Investigation. 91 (5): 2260–7. doi:10.1172/JCI116453. PMC 288229. PMID 8387545.
Reid A, Gould A, Brand N, Cook M, Strutt P, Li J, Licht J, Waxman S, et al. (1995). "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors". Blood. 86 (12): 4544–52. PMID 8541544.
Dong S, Zhu J, Reid A, Strutt P, Guidez F, Zhong HJ, Wang ZY, Licht J, et al. (1996). "Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (8): 3624–9. doi:10.1073/pnas.93.8.3624. PMC 39661. PMID 8622986.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hong SH, David G, Wong CW, Dejean A, Privalsky ML (1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9028–33. doi:10.1073/pnas.94.17.9028. PMC 23013. PMID 9256429.
Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, et al. (1997). "Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10255–60. doi:10.1073/pnas.94.19.10255. PMC 23349. PMID 9294197.
Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. doi:10.1038/35895. PMID 9486654.
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood. 91 (8): 2634–42. doi:10.1182/blood.V91.8.2634.2634_2634_2642. PMID 9531570.
David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
Ahmad KF, Engel CK, Privé GG (1998). "Crystal structure of the BTB domain from PLZF". Proceedings of the National Academy of Sciences of the United States of America. 95 (21): 12123–8. doi:10.1073/pnas.95.21.12123. PMC 22795. PMID 9770450.
van Schothorst EM, Prins DE, Baysal BE, Beekman M, Licht JD, Waxman S, Zelent A, Cornelisse CJ, et al. (1999). "Genomic structure of the human PLZF gene". Gene. 236 (1): 21–4. doi:10.1016/S0378-1119(99)00277-2. PMID 10433962.
Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD (1999). "The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase". Nucleic Acids Research. 27 (20): 4106–13. doi:10.1093/nar/27.20.4106. PMC 148680. PMID 10497277.
Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, et al. (1999). "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11422–7. doi:10.1073/pnas.96.20.11422. PMC 18049. PMID 10500192.
Li X, Peng H, Schultz DC, Lopez-Guisa JM, Rauscher FJ, Marmorstein R (1999). "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein". Cancer Research. 59 (20): 5275–82. PMID 10537309.
Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, et al. (1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. PMID 10572087.
Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (2000). "The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein". Molecular and Cellular Biology. 20 (6): 2075–86. doi:10.1128/MCB.20.6.2075-2086.2000. PMC 110824. PMID 10688654.
Hyman J, Chen H, Di Fiore PP, De Camilli P, Brunger AT (2000). "Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)". The Journal of Cell Biology. 149 (3): 537–46. doi:10.1083/jcb.149.3.537. PMC 2174850. PMID 10791968.
Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47. PMID 11090081.
Beez S, Demmer P, Puccetti E (2012). "Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides". PLoS ONE. 7 (11): e48636. doi:10.1371/journal.pone.0048636. PMC 3494703. PMID 23152790.
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پیوند به بیرون

ZBTB16 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000066687 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993). "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal. 12 (3): 1161–7. doi:10.1002/j.1460-2075.1993.tb05757.x. PMC 413318. PMID 8384553.

[5] Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, et al. (2008). "The BTB-zinc finger transcriptional regulator, PLZF, controls the development of iNKT cell effector functions". Nature Immunology. 9 (9): 1055–64. doi:10.1038/ni.1641. PMC 2662733. PMID 18660811.

[6] Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A (2008). "The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage". Immunity. 29 (3): 391–403. doi:10.1016/j.immuni.2008.07.011. PMC 2613001. PMID 18703361.

[7] Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H (2009). "TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity". Proceedings of the National Academy of Sciences of the United States of America. 106 (30): 12453–8. doi:10.1073/pnas.0903895106. PMC 2718370. PMID 19617548.

[8] Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, et al. (1999). "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11422–7. doi:10.1073/pnas.96.20.11422. PMC 18049. PMID 10500192.

[entrez-9] "ZBTB16 zinc finger and BTB domain containing 16". Entrez. 4 October 2009. Retrieved 10 October 2009.