فاکتور رونویسی Sp1

SP1
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SP1, 1SP2, 1VA1, 1VA2, 1VA3
معین‌کننده‌ها
نام‌های دیگر	SP1, entrez:6667, Sp1 transcription factor
شناسه‌های بیرونی	OMIM: 189906 MGI: 98372 HomoloGene: 8276 GeneCards: SP1
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[1]
End	102,436,404 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • HMG box domain binding; • transcription factor binding; • histone deacetylase binding; • metal ion binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • bHLH transcription factor binding; • protein C-terminus binding; • GO:0001948 پیوند پروتئینی; • histone acetyltransferase binding; • nucleic acid binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • DNA binding; • double-stranded DNA binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • core promoter sequence-specific DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001158 cis-regulatory region sequence-specific DNA binding;
ترکیبات سلولی	• سیتوپلاسم; • نوکلئوپلاسم; • protein-DNA complex; • هسته یاخته; • transcription repressor complex;
فرایند زیستی	• positive regulation of hydrogen sulfide biosynthetic process; • rhythmic process; • regulation of transcription by RNA polymerase II; • positive regulation of transcription, DNA-templated; • GO:0022415 viral process; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • snRNA transcription by RNA polymerase II; • cellular response to insulin stimulus; • positive regulation of transcription by RNA polymerase II; • regulation of cholesterol biosynthetic process; • positive regulation of gene expression; • positive regulation of blood vessel endothelial cell migration; • positive regulation of angiogenesis; • positive regulation of vascular endothelial cell proliferation; • response to hydroperoxide;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6667
	20683
	ENSG00000185591
	ENSMUSG00000001280
	P08047
	O89090
	NM_003109، NM_138473 NM_001251825، NM_003109، NM_138473
	XM_017316523 NM_013672، XM_017316523
	NP_003100، NP_612482 NP_001238754، NP_003100، NP_612482
	XP_017172012 NP_038700، XP_017172012
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

فاکتور رونویسی Sp1 (انگلیسی: Sp1 transcription factor‎) یک پروتئین است که در انسان توسط ژن «SP1» کُدگذاری می‌شود.[4]

این پروتئین در بسیاری از فرایندهای سلولی نظیر رشد سلول، خزان یاخته‌ای، پاسخ ایمنی، پاسخ به آسیب دی‌ان‌ای و بازآرایی کروماتین نقش دارد.

ویتافرین ای که از گیلاس زمستانی بدست می‌آید، این فاکتور رونویسی را مهار می‌کند.[5]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000001280 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Sp1 transcription factor".
Prasanna KS, Shilpa P, Salimath BP (2009). "Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription" (PDF). Current Trends in Biotechnology and Pharmacy. 3 (2): 138–148.

مشارکت‌کنندگان ویکی‌پدیا. «Sp1 transcription factor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر

Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF (2001). "Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors". J. Biol. Chem. 276 (31): 29466–78. doi:10.1074/jbc.M102604200. PMID 11340073.
Tseng L, Gao J, Mazella J, Zhu HH, Lane B (1997). "Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium". Ann. N. Y. Acad. Sci. 828: 27–37. doi:10.1111/j.1749-6632.1997.tb48521.x. PMID 9329821.
Dyson N (1998). "The regulation of E2F by pRB-family proteins". Genes Dev. 12 (15): 2245–62. doi:10.1101/gad.12.15.2245. PMID 9694791.
Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". J. Steroid Biochem. Mol. Biol. 85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729.
Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Seelamgari A, Maddukuri A, Berro R, de la Fuente C, Kehn K, Deng L, Dadgar S, Bottazzi ME, Ghedin E, Pumfery A, Kashanchi F (2004). "Role of viral regulatory and accessory proteins in HIV-1 replication". Front. Biosci. 9: 2388–413. doi:10.2741/1403. PMID 15353294.
Le Rouzic E, Benichou S (2005). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
Kamine J, Chinnadurai G (1992). "Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1". J. Virol. 66 (6): 3932–6. PMC 241184. PMID 1583736.
Szpirer J, Szpirer C, Riviere M, Levan G, Marynen P, Cassiman JJ, Wiese R, DeLuca HF (1991). "The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7". Genomics. 11 (1): 168–73. doi:10.1016/0888-7543(91)90114-T. PMID 1662663.
Gumucio DL, Rood KL, Blanchard-McQuate KL, Gray TA, Saulino A, Collins FS (1991). "Interaction of Sp1 with the human gamma globin promoter: binding and transactivation of normal and mutant promoters". Blood. 78 (7): 1853–63. PMID 1912570.
Kamine J, Subramanian T, Chinnadurai G (1991). "Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein". Proc. Natl. Acad. Sci. U.S.A. 88 (19): 8510–4. doi:10.1073/pnas.88.19.8510. PMC 52538. PMID 1924310.
Courey AJ, Holtzman DA, Jackson SP, Tjian R (1989). "Synergistic activation by the glutamine-rich domains of human transcription factor Sp1". Cell. 59 (5): 827–36. doi:10.1016/0092-8674(89)90606-5. PMID 2512012.
Harrich D, Garcia J, Wu F, Mitsuyasu R, Gonazalez J, Gaynor R (1989). "Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 63 (6): 2585–91. PMC 250732. PMID 2657100.
Jackson SP, Tjian R (1988). "O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation". Cell. 55 (1): 125–33. doi:10.1016/0092-8674(88)90015-3. PMID 3139301.
Kadonaga JT, Carner KR, Masiarz FR, Tjian R (1987). "Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain". Cell. 51 (6): 1079–90. doi:10.1016/0092-8674(87)90594-0. PMID 3319186.
Zhang R, Min W, Sessa WC (1995). "Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells". J. Biol. Chem. 270 (25): 15320–6. doi:10.1074/jbc.270.25.15320. PMID 7541039.
Hagen G, Dennig J, Preiss A, Beato M, Suske G (1995). "Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3". J. Biol. Chem. 270 (42): 24989–94. doi:10.1074/jbc.270.42.24989. PMID 7559627.
Datta PK, Raychaudhuri P, Bagchi S (1995). "Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription". Mol. Cell. Biol. 15 (10): 5444–52. doi:10.1128/mcb.15.10.5444. PMC 230794. PMID 7565695.
Wang L, Mukherjee S, Jia F, Narayan O, Zhao LJ (1995). "Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat". J. Biol. Chem. 270 (43): 25564–9. doi:10.1074/jbc.270.43.25564. PMID 7592727.
Howcroft TK, Palmer LA, Brown J, Rellahan B, Kashanchi F, Brady JN, Singer DS (1995). "HIV Tat represses transcription through Sp1-like elements in the basal promoter". Immunity. 3 (1): 127–38. doi:10.1016/1074-7613(95)90165-5. PMID 7621073.
Ferrari N, Desmarais D, Royal A (1995). "Transcriptional activation of the neuronal peripherin-encoding gene depends on a G + C-rich element that binds Sp1 in vitro and in vivo". Gene. 159 (2): 159–65. doi:10.1016/0378-1119(95)00140-2. PMID 7622044.
Tan NY, Midgley VC, Kavurma MM, Santiago FS, Luo X, Peden R, Fahmy RG, Berndt MC, Molloy MP, Khachigian LM (2008). "Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1". Circ. Res. 102 (4): e38–51. doi:10.1161/CIRCRESAHA.107.167395. PMID 18258854.

پیوند به بیرون

Sp1 Transcription Factor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
SP1 در دانشنامهٔ اجزای دی‌ان‌ای

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000001280 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: Sp1 transcription factor".

[Prasanna_2009-5] Prasanna KS, Shilpa P, Salimath BP (2009). "Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription" (PDF). Current Trends in Biotechnology and Pharmacy. 3 (2): 138–148.