FOXA1
پروتئین A1 جعبه سرچنگالی (به انگلیسی: Forkhead box protein A1) یا به اختصار FOXA1 که با نام فاکتور ۳-آلفا هستهای هپاتوسیت (HNF-3A) هم شناخته میشود، یک پروتئین است که در انسان توسط ژن «FOXA1» کُدگذاری میشود.[4][5][6]
عملکرد
این پروتئین یکی از اعضای خانوادهٔ پروتئینهای FOX است که به دیانای متصل میشوند و فعالکنندههای رونویسی مولکولهای خاص کبدی همچون آلبومین و ترانستیرتین هستند و با کروماتین نیز واکنش نشان میدهند. این پروتئین همچنین یک نشانگر زیستی در سرطان پستان است.
اهمیت بالینی
جهش در ژن «FOXA1» سرطان پروستات مشاهده شدهاست.[7] میزان بیانِ این ژن همچنین با دو نشانگر زیستی دیگر در سرطان پستان (یعنی ئی-کادهرین و TWIST1) مطابقت دارد.[8]
منابع
- GRCm38: Ensembl release 89: ENSMUSG00000035451 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: forkhead box A1".
- Bingle CD, Gowan S (1996). "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line". Biochim Biophys Acta. 1307 (1): 17–20. doi:10.1016/0167-4781(96)00058-9. PMID 8652662.
- Mincheva A, Lichter P, Schütz G, Kaestner KH (1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385.
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- BenAyed-Guerfali, Dorra; Dabbèche-Bouricha, Emna; Ayadi, Wajdi; Trifa, Fatma; Charfi, Slim; Khabir, Abdelmajid; Sellami-Boudawara, Tahia; Mokdad-Gargouri, Raja (2019). "Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer". Molecular Biology Reports. 46 (3): 3247–3255. doi:10.1007/s11033-019-04784-w. ISSN 0301-4851. PMID 30941644.
- مشارکتکنندگان ویکیپدیا. «FOXA1». در دانشنامهٔ ویکیپدیای انگلیسی.
برای مطالعهٔ بیشتر
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