FOXA1

FOXA1
معین‌کننده‌ها
نام‌های دیگر	FOXA1, HNF3A, TCF3A, forkhead box A1
شناسه‌های بیرونی	OMIM: 602294 MGI: 1347472 HomoloGene: 3307 GeneCards: FOXA1
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[1]
End	57,546,916 bp[1]
هستی‌شناسی ژن
عملکرد ملکولی	• sequence-specific DNA binding; • protein domain specific binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	• microvillus; • هسته یاخته; • fibrillar center; • نوکلئوپلاسم;
فرایند زیستی	• Notch signaling pathway; • prostate gland stromal morphogenesis; • dopaminergic neuron differentiation; • positive regulation of intracellular estrogen receptor signaling pathway; • response to estradiol; • regulation of transcription, DNA-templated; • lung morphogenesis; • glucose homeostasis; • positive regulation of smoothened signaling pathway; • lung development; • regulation of transcription by RNA polymerase II; • neuron fate specification; • anatomical structure formation involved in morphogenesis; • positive regulation of mitotic cell cycle; • positive regulation of DNA-binding transcription factor activity; • negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • tube morphogenesis; • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; • transcription, DNA-templated; • regulation of cell cycle; • multicellular organism development; • prostate gland epithelium morphogenesis; • connective tissue development; • positive regulation of neuron differentiation; • epithelial cell maturation involved in prostate gland development; • ساماندهی بیان ژن; • lung epithelial cell differentiation; • dorsal/ventral neural tube patterning; • epithelial-mesenchymal signaling involved in prostate gland development; • epithelial tube branching involved in lung morphogenesis; • respiratory basal cell differentiation; • hormone metabolic process; • alveolar secondary septum development; • negative regulation of epithelial to mesenchymal transition; • positive regulation of cell-cell adhesion mediated by cadherin; • positive regulation of transcription by RNA polymerase II; • chromatin remodeling; • anatomical structure morphogenesis; • positive regulation of apoptotic process; • chromatin organization; • دگرگونی یاخته‌;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3169
	15375
	ENSG00000129514
	ENSMUSG00000035451
	P55317
	P35582
	XM_017021246 NM_004496، XM_017021246
	XM_006515479، XM_006515481، XM_006515483، XM_017314962، XM_030246562 NM_008259، XM_006515479، XM_006515481، XM_006515483، XM_017314962، XM_030246562
	XP_016876735 NP_004487، XP_016876735
	XP_006515542، XP_006515544، XP_006515546، XP_017170451، XP_030102422 NP_032285، XP_006515542، XP_006515544، XP_006515546، XP_017170451، XP_030102422
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین A1 جعبه سرچنگالی (به انگلیسی: Forkhead box protein A1) یا به اختصار FOXA1 که با نام فاکتور ۳-آلفا هسته‌ای هپاتوسیت (HNF-3A) هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «FOXA1» کُدگذاری می‌شود.[4][5][6]

عملکرد

این پروتئین یکی از اعضای خانوادهٔ پروتئین‌های FOX است که به دی‌ان‌ای متصل می‌شوند و فعال‌کننده‌های رونویسی مولکول‌های خاص کبدی همچون آلبومین و ترانس‌تیرتین هستند و با کروماتین نیز واکنش نشان می‌دهند. این پروتئین همچنین یک نشانگر زیستی در سرطان پستان است.

اهمیت بالینی

جهش در ژن «FOXA1» سرطان پروستات مشاهده شده‌است.[7] میزان بیانِ این ژن همچنین با دو نشانگر زیستی دیگر در سرطان پستان (یعنی ئی-کادهرین و TWIST1) مطابقت دارد.[8]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000035451 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: forkhead box A1".
Bingle CD, Gowan S (1996). "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line". Biochim Biophys Acta. 1307 (1): 17–20. doi:10.1016/0167-4781(96)00058-9. PMID 8652662.
Mincheva A, Lichter P, Schütz G, Kaestner KH (1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385.
Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (June 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nat. Genet. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022. PMID 22610119.
BenAyed-Guerfali, Dorra; Dabbèche-Bouricha, Emna; Ayadi, Wajdi; Trifa, Fatma; Charfi, Slim; Khabir, Abdelmajid; Sellami-Boudawara, Tahia; Mokdad-Gargouri, Raja (2019). "Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer". Molecular Biology Reports. 46 (3): 3247–3255. doi:10.1007/s11033-019-04784-w. ISSN 0301-4851. PMID 30941644.

مشارکت‌کنندگان ویکی‌پدیا. «FOXA1». در دانشنامهٔ ویکی‌پدیای انگلیسی.

برای مطالعهٔ بیشتر

Song L, Xu Z, Zhang C, et al. (2009). "Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast cancer cell line". Biochem. Biophys. Res. Commun. 386 (1): 30–4. doi:10.1016/j.bbrc.2009.05.120. PMID 19486887.
Zhang Y, Ali TZ, Zhou H, et al. (2010). "ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer". Cancer Res. 70 (1): 240–8. doi:10.1158/0008-5472.CAN-09-2904. PMC 3724404. PMID 20048076.
McMullin RP, Dobi A, Mutton LN, et al. (2010). "A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland". Proc. Natl. Acad. Sci. U.S.A. 107 (1): 98–103. doi:10.1073/pnas.0902001107. PMC 2806740. PMID 20018680.
Sun Q, Yu X, Degraff DJ, Matusik RJ (2009). "Upstream stimulatory factor 2, a novel FoxA1-interacting protein, is involved in prostate-specific gene expression". Mol. Endocrinol. 23 (12): 2038–47. doi:10.1210/me.2009-0092. PMC 2796152. PMID 19846536.
Liu N, Niu Y, Wang SL, et al. (2010). "[Diagnostic and prognostic significance of FOXA1 expression in molecular subtypes of breast invasive ductal carcinomas]". Zhonghua Yi Xue Za Zhi. 90 (20): 1403–7. PMID 20646630.
Haiman CA, Garcia RR, Hsu C, et al. (2009). "Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort". BMC Cancer. 9: 43. doi:10.1186/1471-2407-9-43. PMC 2637888. PMID 19183483.
Kohler S, Cirillo LA (2010). "Stable chromatin binding prevents FoxA acetylation, preserving FoxA chromatin remodeling". J. Biol. Chem. 285 (1): 464–72. doi:10.1074/jbc.M109.063149. PMC 2804194. PMID 19897491.
Malik S, Jiang S, Garee JP, et al. (2010). "Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM". Mol. Cell. Biol. 30 (2): 399–412. doi:10.1128/MCB.00907-09. PMC 2798473. PMID 19917725.
Motallebipour M, Ameur A, Reddy Bysani MS, et al. (2009). "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq". Genome Biol. 10 (11): R129. doi:10.1186/gb-2009-10-11-r129. PMC 3091322. PMID 19919681.
Eeckhoute J, Lupien M, Meyer CA, et al. (2009). "Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers". Genome Res. 19 (3): 372–80. doi:10.1101/gr.084582.108. PMC 2661808. PMID 19129543.
Nakshatri H, Badve S (2007). "FOXA1 as a therapeutic target for breast cancer". Expert Opin. Ther. Targets. 11 (4): 507–14. doi:10.1517/14728222.11.4.507. PMID 17373880.
Iacobazzi V, Infantino V, Bisaccia F, et al. (2009). "Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion". Biochem. Biophys. Res. Commun. 385 (2): 220–4. doi:10.1016/j.bbrc.2009.05.030. PMID 19445897.
Nucera C, Eeckhoute J, Finn S, et al. (2009). "FOXA1 is a potential oncogene in anaplastic thyroid carcinoma". Clin. Cancer Res. 15 (11): 3680–9. doi:10.1158/1078-0432.CCR-08-3155. PMID 19470727.
Nakshatri H, Badve S (2009). "FOXA1 in breast cancer". Expert Rev Mol Med. 11: e8. doi:10.1017/S1462399409001008. PMID 19261198.
Song Y, Washington MK, Crawford HC (2010). "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer". Cancer Res. 70 (5): 2115–25. doi:10.1158/0008-5472.CAN-09-2979. PMC 2831111. PMID 20160041.
Lee HJ, Chattopadhyay S, Yoon WH, et al. (2010). "Overexpression of hepatocyte nuclear factor-3alpha induces apoptosis through the upregulation and accumulation of cytoplasmic p53 in prostate cancer cells". Prostate. 70 (4): 353–61. doi:10.1002/pros.21069. PMID 19866472.
Bernardo GM, Lozada KL, Miedler JD, et al. (2010). "FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis". Development. 137 (12): 2045–54. doi:10.1242/dev.043299. PMC 2875844. PMID 20501593.
Albergaria A, Paredes J, Sousa B, et al. (2009). "Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours". Breast Cancer Res. 11 (3): R40. doi:10.1186/bcr2327. PMC 2716509. PMID 19549328.
Huang QY, Li GH, Kung AW (2009). "The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis". Bone. 45 (2): 289–94. doi:10.1016/j.bone.2009.03.676. PMID 19371798.
Sano M, Aoyagi K, Takahashi H, et al. (2010). "Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis". Int. J. Oncol. 36 (2): 321–30. doi:10.3892/ijo_00000503. PMID 20043065.

پیوند به بیرون

FOXA1 در دانشنامهٔ اجزای دی‌ان‌ای

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000035451 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: forkhead box A1".

[pmid8652662-5] Bingle CD, Gowan S (1996). "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line". Biochim Biophys Acta. 1307 (1): 17–20. doi:10.1016/0167-4781(96)00058-9. PMID 8652662.

[pmid9119385-6] Mincheva A, Lichter P, Schütz G, Kaestner KH (1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385.

[Barbieri_2012-7] Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (June 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nat. Genet. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022. PMID 22610119.

[8] BenAyed-Guerfali, Dorra; Dabbèche-Bouricha, Emna; Ayadi, Wajdi; Trifa, Fatma; Charfi, Slim; Khabir, Abdelmajid; Sellami-Boudawara, Tahia; Mokdad-Gargouri, Raja (2019). "Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer". Molecular Biology Reports. 46 (3): 3247–3255. doi:10.1007/s11033-019-04784-w. ISSN 0301-4851. PMID 30941644.