N-Myc

MYCN
معین‌کننده‌ها
نام‌های دیگر	MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor
شناسه‌های بیرونی	OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[1]
End	12,941,914 bp[1]
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• DNA binding; • protein dimerization activity; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0001948 پیوند پروتئینی; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • kinase binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	• کروماتین; • هسته یاخته; • هستک;
فرایند زیستی	• regulation of transcription, DNA-templated; • regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • positive regulation of gene expression; • negative regulation of gene expression; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • transcription by RNA polymerase II; • cartilage condensation; • positive regulation of mesenchymal cell proliferation; • positive regulation of cell population proliferation; • positive regulation of cell death; • lung development; • embryonic digit morphogenesis; • regulation of inner ear auditory receptor cell differentiation; • positive regulation of transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • embryonic skeletal system morphogenesis; • negative regulation of astrocyte differentiation; • branching morphogenesis of an epithelial tube; • negative regulation of reactive oxygen species metabolic process;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4613
	18109
	ENSG00000134323
	ENSMUSG00000037169
	P04198
	P03966
	NM_001293228، NM_001293231، NM_001293233 NM_005378، NM_001293228، NM_001293231، NM_001293233
	NM_008709
	NP_001280160، NP_001280162، NP_005369 NP_001280157، NP_001280160، NP_001280162، NP_005369
	NP_032735
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین پروتو-آنکوژن N-Myc (انگلیسی: N-myc proto-oncogene protein‎) یا پروتئین مارپیچ-حلقه-مارپیچ قلیایی ۳۷ که با نام‌های اختصاری «N-Myc» و «bHLHe37» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «MYCN» کدگذاری می‌شود.

این ژن یکی از اعضای خانوادهٔ MYCN است که گروهی از فاکتورهای رونویسی بوده و یک دومین مارپیچ-حلقه-مارپیچ قلیایی دارند. پروتئین ساخته شده توسط این ژن، در درون هسته جای دارد و به‌منظور اتصال به دی‌ان‌ای، می‌بایست با پروتئین دیگری، یک ساختار دوتایی تشکیل دهند. (دایمریزه شوند).[4] پروتئین N-Myc در مغز جنین در مقادیر زیاد ساخته می‌شود و برای رشد و تکامل طبیعی مغز ضروری است.[5]

تشدید فعالیت یا تولید بیش از حدِ N-Myc سبب بروز تومور می‌شود. مقادیر زیاد این پروتئین با تومورهای گوناگونی به‌ویژه نوروبلاستوما در ارتباط نزدیک است، به نحوی که تشدید و افزایش فعالیت آن با پیش‌اگهی بد نوروبلاستوما مرتبط است.[6][7][8]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000037169 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)".
Knoepfler PS, Cheng PF, Eisenman RN (2002). "N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation". Genes Dev. 16 (20): 2699–712. doi:10.1101/gad.1021202. PMC 187459. PMID 12381668.
Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet. 4 (2): 191–4. doi:10.1038/ng0693-191. PMID 8102299.
Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423.
Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage". Science. 224 (4653): 1121–4. doi:10.1126/science.6719137. PMID 6719137.

مشارکت‌کنندگان ویکی‌پدیا. «N-Myc». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۹ آوریل ۲۰۱۸.

بیشتر بخوانید

Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1–2): 1–14. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341.
Hagiwara T, Nakaya K, Nakamura Y, Nakajima H, Nishimura S, Taya Y (1992). "Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II". Eur. J. Biochem. 209 (3): 945–50. doi:10.1111/j.1432-1033.1992.tb17367.x. PMID 1425701.
Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1)". Nucleic Acids Res. 20 (5): 1165. doi:10.1093/nar/20.5.1165. PMC 312136. PMID 1549498.
Krystal GW, Armstrong BC, Battey JF (1990). "N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts". Mol. Cell. Biol. 10 (8): 4180–91. PMC 360949. PMID 1695323.
Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–7. doi:10.1126/science.2006410. PMID 2006410.
Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423.
Ibson JM, Rabbitts PH (1988). "Sequence of a germ-line N-myc gene and amplification as a mechanism of activation". Oncogene. 2 (4): 399–402. PMID 2834684.
Stanton LW, Schwab M, Bishop JM (1986). "Nucleotide sequence of the human N-myc gene". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1772–6. doi:10.1073/pnas.83.6.1772. PMC 323166. PMID 2869488.
Michitsch RW, Melera PW (1985). "Nucleotide sequence of the 3' exon of the human N-myc gene". Nucleic Acids Res. 13 (7): 2545–58. doi:10.1093/nar/13.7.2545. PMC 341174. PMID 2987858.
Slamon DJ, Boone TC, Seeger RC, Keith DE, Chazin V, Lee HC, Souza LM (1986). "Identification and characterization of the protein encoded by the human N-myc oncogene". Science. 232 (4751): 768–72. doi:10.1126/science.3008339. PMID 3008339.
Garson JA, van den Berghe JA, Kemshead JT (1987). "Novel non-isotopic in situ hybridization technique detects small (1 Kb) unique sequences in routinely G-banded human chromosomes: fine mapping of N-myc and beta-NGF genes". Nucleic Acids Res. 15 (12): 4761–70. doi:10.1093/nar/15.12.4761. PMC 305916. PMID 3299258.
Stanton LW, Bishop JM (1988). "Alternative processing of RNA transcribed from NMYC". Mol. Cell. Biol. 7 (12): 4266–72. PMC 368108. PMID 3437890.
Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW (1986). "Human N-myc is closely related in organization and nucleotide sequence to c-myc". Nature. 319 (6048): 73–7. doi:10.1038/319073a0. PMID 3510398.
Grady EF, Schwab M, Rosenau W (1987). "Expression of N-myc and c-src during the development of fetal human brain". Cancer Res. 47 (11): 2931–6. PMID 3552210.
Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA". Mol. Cell. Biol. 6 (12): 4450–7. PMC 367228. PMID 3796607.
Brodeur GM, Seeger RC (1986). "Gene amplification in human neuroblastomas: basic mechanisms and clinical implications". Cancer Genet. Cytogenet. 19 (1–2): 101–11. doi:10.1016/0165-4608(86)90377-8. PMID 3940169.
Kanda N, Schreck R, Alt F, Bruns G, Baltimore D, Latt S (1983). "Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes". Proc. Natl. Acad. Sci. U.S.A. 80 (13): 4069–73. doi:10.1073/pnas.80.13.4069. PMC 394202. PMID 6575396.
Schwab M, Varmus HE, Bishop JM, Grzeschik KH, Naylor SL, Sakaguchi AY, Brodeur G, Trent J (1984). "Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc". Nature. 308 (5956): 288–91. doi:10.1038/308288a0. PMID 6700732.

پیوند به بیرون

MYCN protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000037169 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)".

[5] Knoepfler PS, Cheng PF, Eisenman RN (2002). "N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation". Genes Dev. 16 (20): 2699–712. doi:10.1101/gad.1021202. PMC 187459. PMID 12381668.

[pmid8102299-6] Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet. 4 (2): 191–4. doi:10.1038/ng0693-191. PMID 8102299.

[7] Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423.

[8] Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage". Science. 224 (4653): 1121–4. doi:10.1126/science.6719137. PMID 6719137.