گیرنده گامای رتینوئیک اسید

RARG
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EXA, 1EXX, 1FCX, 1FCY, 1FCZ, 1FD0, 2LBD, 3LBD, 4LBD
معین‌کننده‌ها
نام‌های دیگر	RARG, NR1B3, RARC, retinoic acid receptor gamma
شناسه‌های بیرونی	OMIM: 180190 MGI: 97858 HomoloGene: 20263 GeneCards: RARG
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[1]
End	102,257,517 bp[1]
هستی‌شناسی ژن
عملکرد ملکولی	• sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • zinc ion binding; • metal ion binding; • steroid hormone receptor activity; • GO:0001948 پیوند پروتئینی; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • DNA binding; • retinoid X receptor binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000975 transcription cis-regulatory region binding; • transcription factor binding; • nuclear receptor coactivator activity; • signaling receptor activity; • GO:0038050، GO:0004886، GO:0038051 nuclear receptor activity;
ترکیبات سلولی	• integral component of membrane; • نوکلئوپلاسم; • هسته یاخته; • transcription regulator complex; • RNA polymerase II transcription regulator complex;
فرایند زیستی	• regulation of cell size; • growth plate cartilage development; • cellular response to retinoic acid; • gland development; • regulation of transcription, DNA-templated; • negative regulation of cartilage development; • response to retinoic acid; • multicellular organism growth; • negative regulation of cell differentiation; • bone morphogenesis; • chondrocyte development; • negative regulation of apoptotic process; • retinal pigment epithelium development; • transcription, DNA-templated; • epithelium development; • embryonic camera-type eye development; • reproductive structure development; • limb development; • face development; • neural tube closure; • negative regulation of chondrocyte differentiation; • Harderian gland development; • prostate gland epithelium morphogenesis; • regulation of myelination; • positive regulation of gene expression; • retina development in camera-type eye; • positive regulation of cell population proliferation; • growth plate cartilage chondrocyte growth; • canonical Wnt signaling pathway; • ساماندهی بیان ژن; • camera-type eye development; • transcription initiation from RNA polymerase II promoter; • regulation of myeloid cell differentiation; • bone development; • trachea cartilage development; • anterior/posterior pattern specification; • glandular epithelial cell development; • steroid hormone mediated signaling pathway; • negative regulation of transcription by RNA polymerase II; • positive regulation of transcription by RNA polymerase II; • embryonic hindlimb morphogenesis; • retinoic acid receptor signaling pathway; • negative regulation of cell population proliferation; • embryonic eye morphogenesis; • positive regulation of apoptotic process; • positive regulation of programmed cell death; • cellular response to leukemia inhibitory factor; • multicellular organism development; • hormone-mediated signaling pathway; • دگرگونی یاخته‌; • response to lipid;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5916
	19411
	ENSG00000172819
	ENSMUSG00000001288
	P13631
	P18911
	NM_001042728، NM_001243730، NM_001243731، NM_001243732، XM_024449112، XM_024449113، XM_024449114 NM_000966، NM_001042728، NM_001243730، NM_001243731، NM_001243732، XM_024449112، XM_024449113، XM_024449114
	NM_011244، XM_006520650، XM_011245525 NM_001042727، NM_011244، XM_006520650، XM_011245525
	NP_001036193، NP_001230659، NP_001230660، NP_001230661، XP_024304880، XP_024304881، XP_024304882 NP_000957، NP_001036193، NP_001230659، NP_001230660، NP_001230661، XP_024304880، XP_024304881، XP_024304882
	NP_035374، XP_006520713 NP_001036192، NP_035374، XP_006520713
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

گیرنده گامای رتینوئیک اسید (انگلیسی: Retinoic acid receptor gamma‎) یا به اختصار RAR-γ، یک پروتئین است که در انسان توسط ژن «RARG» کُدگذاری می‌شود.[4][5]

این پروتئین، یک گیرنده هسته‌ای، و یکی از انواع گیرنده‌های رتینوئیک اسید است.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000001288 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: RARG retinoic acid receptor, gamma".
Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.

مشارکت‌کنندگان ویکی‌پدیا. «Retinoic acid receptor gamma». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر

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Lehmann JM, Zhang XK, Pfahl M (Jul 1992). "RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites". Molecular and Cellular Biology. 12 (7): 2976–85. doi:10.1128/mcb.12.7.2976. PMC 364511. PMID 1320193.
Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P (Aug 1991). "Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes" (PDF). Genomics. 10 (4): 1061–9. doi:10.1016/0888-7543(91)90199-O. PMID 1655630.
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Zhou L, Pang J, Munroe DG, Lau C (May 1993). "A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7". Nucleic Acids Research. 21 (10): 2520. doi:10.1093/nar/21.10.2520. PMC 309563. PMID 7685085.
Zitnik RJ, Kotloff RM, Latifpour J, Zheng T, Whiting NL, Schwalb J, Elias JA (Feb 1994). "Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts". Journal of Immunology. 152 (3): 1419–27. PMID 8301142.
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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000001288 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: RARG retinoic acid receptor, gamma".

[pmid1849262-5] Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.