گیرنده آلفای رتینوئیک اسید

RARA
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13
معین‌کننده‌ها
نام‌های دیگر	RARA, NR1B1, RAR, retinoic acid receptor alpha
شناسه‌های بیرونی	OMIM: 180240 MGI: 97856 HomoloGene: 20262 GeneCards: RARA
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[1]
End	98,974,942 bp[1]
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• retinoic acid binding; • GO:0001106 transcription corepressor activity; • protein domain specific binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0038050، GO:0004886، GO:0038051 nuclear receptor activity; • mRNA 5'-UTR binding; • signaling receptor binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • retinoic acid-responsive element binding; • transcription factor binding; • metal ion binding; • steroid hormone receptor activity; • enzyme binding; • zinc ion binding; • GO:0001948 پیوند پروتئینی; • drug binding; • DNA binding; • sequence-specific DNA binding; • GO:0001105 transcription coactivator activity; • protein kinase A binding; • protein kinase B binding; • translation repressor activity, mRNA regulatory element binding; • alpha-actinin binding; • protein heterodimerization activity; • chromatin DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding; • GO:0000975 transcription cis-regulatory region binding; • nuclear receptor coactivator activity; • signaling receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • actin cytoskeleton; • perinuclear region of cytoplasm; • neuron projection; • هسته یاخته; • cell surface; • نوکلئوپلاسم; • neuronal cell body; • دندریت; • سیتوزول; • RNA polymerase II transcription regulator complex;
فرایند زیستی	• growth plate cartilage development; • germ cell development; • cellular response to retinoic acid; • ureteric bud development; • positive regulation of interleukin-5 production; • prostate gland development; • limb development; • apoptotic cell clearance; • chondroblast differentiation; • regulation of granulocyte differentiation; • protein phosphorylation; • response to vitamin A; • face development; • اسپرماتوژنز; • response to ethanol; • negative regulation of cell population proliferation; • steroid hormone mediated signaling pathway; • regulation of apoptotic process; • response to cytokine; • negative regulation of translation; • regulation of transcription, DNA-templated; • negative regulation of cell differentiation; • negative regulation of gene expression; • transcription, DNA-templated; • cellular response to estrogen stimulus; • positive regulation of transcription, DNA-templated; • positive regulation of cell cycle; • regulation of myelination; • positive regulation of neuron differentiation; • negative regulation of tumor necrosis factor production; • transcription initiation from RNA polymerase II promoter; • trachea cartilage development; • glandular epithelial cell development; • male gonad development; • negative regulation of cartilage development; • response to retinoic acid; • negative regulation of granulocyte differentiation; • multicellular organism growth; • female pregnancy; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • positive regulation of interleukin-4 production; • regulation of synaptic plasticity; • outflow tract septum morphogenesis; • negative regulation of transcription, DNA-templated; • negative regulation of interferon-gamma production; • response to estradiol; • negative regulation of translational initiation; • embryonic camera-type eye development; • positive regulation of interleukin-13 production; • neural tube closure; • positive regulation of binding; • retinoic acid receptor signaling pathway; • positive regulation of gene expression; • Sertoli cell fate commitment; • positive regulation of cell population proliferation; • positive regulation of T-helper 2 cell differentiation; • ventricular cardiac muscle cell differentiation; • liver development; • cellular response to lipopolysaccharide; • bone development; • hippocampus development; • ورارسانی پیام; • positive regulation of transcription by RNA polymerase II; • multicellular organism development; • hormone-mediated signaling pathway; • دگرگونی یاخته‌; • response to lipid; • gland development; • bone morphogenesis; • epithelium development;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5914
	19401
	ENSG00000131759
	ENSMUSG00000037992
	P10276; Q6I9R7
	P11416
	NM_000964، NM_001024809، NM_001033603، NM_001145301، NM_001145302، XM_005257552، XM_005257553، XM_005257554، XM_011525095، XM_017024920 XM_011525096، NM_000964، NM_001024809، NM_001033603، NM_001145301، NM_001145302، XM_005257552، XM_005257553، XM_005257554، XM_011525095، XM_017024920
	NM_001177302، NM_001177303، NM_009024، XM_006532592، XM_006532593، XM_006532597، NM_001361954، XM_030245700، XM_030245701، XM_030245702 NM_001176528، NM_001177302، NM_001177303، NM_009024، XM_006532592، XM_006532593، XM_006532597، NM_001361954، XM_030245700، XM_030245701، XM_030245702
	NP_001019980، NP_001138773، NP_001138774، XP_005257609، XP_005257610، XP_005257611، XP_011523397، XP_011523398، XP_016880409 NP_000955، NP_001019980، NP_001138773، NP_001138774، XP_005257609، XP_005257610، XP_005257611، XP_011523397، XP_011523398، XP_016880409; NP_001138773.1، XP_005257610.1، XP_005257611.1، XP_011523397.1 NP_000955.1، NP_001138773.1، XP_005257610.1، XP_005257611.1، XP_011523397.1
	NP_001170773، NP_001170774، NP_033050، XP_006532655، XP_006532656، XP_006532660، NP_001348883، XP_030101561، XP_030101562 NP_001169999، NP_001170773، NP_001170774، NP_033050، XP_006532655، XP_006532656، XP_006532660، NP_001348883، XP_030101561، XP_030101562
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

گیرنده آلفای رتینوئیک اسید (انگلیسی: Retinoic acid receptor alpha‎) یا به اختصار RAR-α، یک پروتئین است که در انسان توسط ژن «RARA» کُدگذاری می‌شود.[4][5]

این پروتئین، یک گیرنده هسته‌ای، و یکی از انواع گیرنده‌های رتینوئیک اسید است.

این مولکول با ژن ساعت[6] و همچنین پروتئین‌های ZBTB16[7] و C-Src[8][9] تعامل پروتئین-پروتئین دارد.

اهمیت بالینی

جابجایی‌های کروموزومی که منجر به تغییر مکان جایگاه ژنی این پروتئین گردد، به ویژه اگر از نوع t(15,17)(q21;q22) باشد در بروز لوسمی پرومیلوسیتیک حاد نقش دارد.[10]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000037992 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Giguere V, Ong ES, Segui P, Evans RM (1987). "Identification of a receptor for the morphogen retinoic acid". Nature. 330 (6149): 624–9. doi:10.1038/330624a0. PMID 2825036.
Anderson LA, Friedman L, Osborne-Lawrence S, Lynch E, Weissenbach J, Bowcock A, King MC (September 1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21". Genomics. 17 (3): 618–23. doi:10.1006/geno.1993.1381. PMID 8244378.
McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (June 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell. 105 (7): 877–89. doi:10.1016/S0092-8674(01)00401-9. PMID 11439184.
Martin PJ, Delmotte MH, Formstecher P, Lefebvre P (September 2003). "PLZF is a negative regulator of retinoic acid receptor transcriptional activity". Nucl. Recept. 1 (1): 6. doi:10.1186/1478-1336-1-6. PMC 212040. PMID 14521715.
Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (September 1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.
He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
Vitoux D, Nasr R, de The H (2007). "Acute promyelocytic leukemia: new issues on pathogenesis and treatment response". Int. J. Biochem. Cell Biol. 39 (6): 1063–70. doi:10.1016/j.biocel.2007.01.028. PMID 17468032.

مشارکت‌کنندگان ویکی‌پدیا. «Retinoic acid receptor alpha». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر

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Sirulnik A, Melnick A, Zelent A, Licht JD (2003). "Molecular pathogenesis of acute promyelocytic leukaemia and APL variants". Best Pract Res Clin Haematol. 16 (3): 387–408. doi:10.1016/S1521-6926(03)00062-8. PMID 12935958.
Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (1992). "Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling". Nature. 355 (6359): 446–9. doi:10.1038/355446a0. PMC 6159885. PMID 1310351.
Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P (1992). "Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins". EMBO J. 11 (2): 629–42. PMC 556495. PMID 1311253.
Baniahmad A, Köhne AC, Renkawitz R (1992). "A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor". EMBO J. 11 (3): 1015–23. PMC 556542. PMID 1347744.
de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A (1991). "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR". Cell. 66 (4): 675–84. doi:10.1016/0092-8674(91)90113-D. PMID 1652369.
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Brand NJ, Petkovich M, Chambon P (1990). "Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha)". Nucleic Acids Res. 18 (23): 6799–806. doi:10.1093/nar/18.23.6799. PMC 332734. PMID 2175878.
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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000037992 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2825036-4] Giguere V, Ong ES, Segui P, Evans RM (1987). "Identification of a receptor for the morphogen retinoic acid". Nature. 330 (6149): 624–9. doi:10.1038/330624a0. PMID 2825036.

[pmid8244378-5] Anderson LA, Friedman L, Osborne-Lawrence S, Lynch E, Weissenbach J, Bowcock A, King MC (September 1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21". Genomics. 17 (3): 618–23. doi:10.1006/geno.1993.1381. PMID 8244378.

[pmid11439184-6] McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (June 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell. 105 (7): 877–89. doi:10.1016/S0092-8674(01)00401-9. PMID 11439184.

[pmid14521715-7] Martin PJ, Delmotte MH, Formstecher P, Lefebvre P (September 2003). "PLZF is a negative regulator of retinoic acid receptor transcriptional activity". Nucl. Recept. 1 (1): 6. doi:10.1186/1478-1336-1-6. PMC 212040. PMID 14521715.

[pmid10454579-8] Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (September 1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

[pmid12612084-9] He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.

[pmid17468032-10] Vitoux D, Nasr R, de The H (2007). "Acute promyelocytic leukemia: new issues on pathogenesis and treatment response". Int. J. Biochem. Cell Biol. 39 (6): 1063–70. doi:10.1016/j.biocel.2007.01.028. PMID 17468032.