SMAD2

SMAD2
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DEV, 1KHX, 1U7V, 2LB3
معین‌کننده‌ها
نام‌های دیگر	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2
شناسه‌های بیرونی	OMIM: 601366 MGI: 108051 HomoloGene: 21197 GeneCards: SMAD2
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[1]
End	76,310,963 bp[1]
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• phosphatase binding; • I-SMAD binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • R-SMAD binding; • co-SMAD binding; • transcription factor binding; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • transforming growth factor beta receptor binding; • type I transforming growth factor beta receptor binding; • protein homodimerization activity; • chromatin binding; • GO:0001948 پیوند پروتئینی; • double-stranded DNA binding; • SMAD binding; • DNA binding; • protein heterodimerization activity; • ubiquitin protein ligase binding; • primary miRNA binding; • disordered domain specific binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • tau protein binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • هسته یاخته; • heteromeric SMAD protein complex; • SMAD protein complex; • transcription regulator complex; • intracellular anatomical structure; • نوکلئوپلاسم; • activin responsive factor complex; • protein-containing complex;
فرایند زیستی	• pattern specification process; • ureteric bud development; • endoderm development; • response to cholesterol; • organ growth; • embryonic pattern specification; • zygotic specification of dorsal/ventral axis; • post-embryonic development; • protein phosphorylation; • pericardium development; • regulation of binding; • transforming growth factor beta receptor signaling pathway; • negative regulation of cell population proliferation; • cell fate commitment; • common-partner SMAD protein phosphorylation; • regulation of transcription, DNA-templated; • SMAD protein signal transduction; • lung development; • signal transduction involved in regulation of gene expression; • insulin secretion; • in utero embryonic development; • negative regulation of transforming growth factor beta receptor signaling pathway; • negative regulation of gene expression; • nodal signaling pathway; • positive regulation of transcription, DNA-templated; • heart development; • pancreas development; • endoderm formation; • activin receptor signaling pathway; • SMAD protein complex assembly; • positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; • embryonic foregut morphogenesis; • negative regulation of transcription by RNA polymerase II; • response to glucose; • positive regulation of epithelial to mesenchymal transition; • developmental growth; • لایه‌زایی; • primary miRNA processing; • positive regulation of BMP signaling pathway; • embryonic cranial skeleton morphogenesis; • negative regulation of transcription, DNA-templated; • paraxial mesoderm morphogenesis; • GO:0007243 intracellular signal transduction; • somatic stem cell population maintenance; • mesoderm formation; • regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of gene expression; • anterior/posterior pattern specification; • positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • transcription by RNA polymerase II; • protein deubiquitination; • بهبود زخم; • adrenal gland development; • secondary palate development;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4087
	17126
	ENSG00000175387
	ENSMUSG00000024563
	Q15796
	Q62432
	NM_001135937، NM_005901، XM_005258259، XM_006722451، XM_011525984، XM_011525985، XM_017025745، XM_017025746، XM_017025747، XM_017025748، XM_017025749، XM_017025750، XM_024451173 NM_001003652، NM_001135937، NM_005901، XM_005258259، XM_006722451، XM_011525984، XM_011525985، XM_017025745، XM_017025746، XM_017025747، XM_017025748، XM_017025749، XM_017025750، XM_024451173
	NM_010754، XM_006525699، NM_001311070، XM_017317842، XM_030250351 NM_001252481، NM_010754، XM_006525699، NM_001311070، XM_017317842، XM_030250351
	NP_001129409، NP_005892، XP_005258316، XP_006722514، XP_011524286، XP_011524287، XP_016881234، XP_016881235، XP_016881236، XP_016881237، XP_016881238، XP_016881239، XP_024306941 NP_001003652، NP_001129409، NP_005892، XP_005258316، XP_006722514، XP_011524286، XP_011524287، XP_016881234، XP_016881235، XP_016881236، XP_016881237، XP_016881238، XP_016881239، XP_024306941
	NP_001297999، NP_034884، XP_006525762، XP_017173331، XP_030106211 NP_001239410، NP_001297999، NP_034884، XP_006525762، XP_017173331، XP_030106211
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

هم‌ساخت ۲ مادران مخالف دکپنتاپلجیک (انگلیسی: Mothers against decapentaplegic homolog 2‎) یک پروتئین است که در انسان توسط ژن «SMAD2» کُدگذاری می‌شود.[4][5]

این پروتئین عضوی از خانواده بزرگ SMAD است که این نیز به نوبهٔ خود، جزئی از اَبَرخانوادهٔ فاکتور رشد تغییردهنده بتا است.

پروتئین SMAD2 در پیام‌رسانی سلولی و ساماندهی بیان ژن نقش دارد.

این پروتئین همچنین با مولکول SMAD3[6][7] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

مادران مخالف دکپنتاپلجیک

منابع

GRCm38: Ensembl release 89: ENSMUSG00000024563 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L (August 1996). "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma". Cell. 86 (4): 543–52. doi:10.1016/S0092-8674(00)80128-2. PMID 8752209.
Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.
Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P (September 1997). "TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4". EMBO J. 16 (17): 5353–62. doi:10.1093/emboj/16.17.5353. ISSN 0261-4189. PMC 1170167. PMID 9311995.
Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor signaling". Mol. Endocrinol. 13 (1): 15–23. doi:10.1210/mend.13.1.0218. ISSN 0888-8809. PMID 9892009.

مشارکت‌کنندگان ویکی‌پدیا. «Mothers against decapentaplegic homolog 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۳ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Wrana JL (1998). "TGF-beta receptors and signalling mechanisms". Mineral and Electrolyte Metabolism. 24 (2–3): 120–30. doi:10.1159/000057359. PMID 9525694.
Massagué J (1998). "TGF-beta signal transduction". Annu. Rev. Biochem. 67: 753–91. doi:10.1146/annurev.biochem.67.1.753. PMID 9759503.
Verschueren K, Huylebroeck D (2000). "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells". Cytokine Growth Factor Rev. 10 (3–4): 187–99. doi:10.1016/S1359-6101(99)00012-X. PMID 10647776.
Wrana JL, Attisano L (2000). "The Smad pathway". Cytokine Growth Factor Rev. 11 (1–2): 5–13. doi:10.1016/S1359-6101(99)00024-6. PMID 10708948.
Miyazono K (2000). "TGF-beta signaling by Smad proteins". Cytokine Growth Factor Rev. 11 (1–2): 15–22. doi:10.1016/S1359-6101(99)00025-8. PMID 10708949.
Zannis VI, Kan HY, Kritis A, Zanni E, Kardassis D (March 2001). "Transcriptional regulation of the human apolipoprotein genes". Front. Biosci. 6: D456–504. doi:10.2741/Zannis. PMID 11229886.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000024563 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8752209-4] Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L (August 1996). "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma". Cell. 86 (4): 543–52. doi:10.1016/S0092-8674(00)80128-2. PMID 8752209.

[pmid8673135-5] Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.

[pmid9311995-6] Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P (September 1997). "TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4". EMBO J. 16 (17): 5353–62. doi:10.1093/emboj/16.17.5353. ISSN 0261-4189. PMC 1170167. PMID 9311995.

[pmid9892009-7] Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor signaling". Mol. Endocrinol. 13 (1): 15–23. doi:10.1210/mend.13.1.0218. ISSN 0888-8809. PMID 9892009.