پروتئین ۳ ریخت‌زایی استخوان

BMP3
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QCQ
معین‌کننده‌ها
نام‌های دیگر	BMP3, BMP-3A, bone morphogenetic protein 3
شناسه‌های بیرونی	OMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[1]
End	98,884,396 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• cytokine activity; • BMP receptor binding; • transforming growth factor beta receptor binding; • growth factor activity; • signaling receptor binding;
ترکیبات سلولی	• extracellular region; • extracellular exosome; • extracellular space;
فرایند زیستی	• regulation of apoptotic process; • skeletal system development; • دگرگونی یاخته‌; • regulation of MAPK cascade; • SMAD protein signal transduction; • cell development; • استخوان‌سازی; • cell-cell signaling; • positive regulation of pathway-restricted SMAD protein phosphorylation; • BMP signaling pathway; • multicellular organism development; • cartilage development; • osteoblast differentiation; • regulation of signaling receptor activity;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	651
	110075
	ENSG00000152785
	ENSMUSG00000029335
	P12645
	Q8BHE5
	NM_001201 XM_006714291، NM_001201
	NM_001310677 NM_173404، NM_001310677
	XP_006714354 NP_001192، XP_006714354
	NP_775580 NP_001297606، NP_775580
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین ۳ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 3‎) یک پروتئین است که در انسان توسط ژن «BMP3» کُدگذاری می‌شود.[4]

این پروتئین عضوی از خانوادهٔ فاکتور رشد تغییردهنده بتا است. پروتئین‌های ریخت‌زایی استخوان قادرند رشد و تکامل غضروف و استخوان را تحریک کنند.

اهمیت بالینی

ژن «BMP3» در بسیاری از مبتلایان به سرطان روده بزرگ هایپرمِـتیله می‌شود و همچون سایر ژن‌های هایپرمتیله، می‌تواند به‌عنوان یک نشانگر زیستی جهت تشخیص مراحل اولیه سرطان روده استفاده شود.[5][6]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (June 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585. S2CID 25724654.
Kormi, Seyed Mohammad Amin; Ardehkhani, Shima; Kerachian, Mohammad Amin (November 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.

مشارکت‌کنندگان ویکی‌پدیا. «Bone morphogenetic protein 3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ مارس ۲۰۲۱.

برای مطالعهٔ بیشتر

Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM (March 1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics. 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330.
Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney JM, Kaplan FS (February 1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics. 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778.
Paralkar VM, Nandedkar AK, Pointer RH, Kleinman HK, Reddi AH (October 1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". The Journal of Biological Chemistry. 265 (28): 17281–4. PMID 2211625.
Rosen V, Wozney JM, Wang EA, Cordes P, Celeste A, McQuaid D, Kurtzberg L (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connective Tissue Research. 20 (1–4): 313–9. doi:10.3109/03008208909023902. PMID 2612162.
Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (December 1988). "Novel regulators of bone formation: molecular clones and activities". Science. 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.
Faucheux C, Ulysse F, Bareille R, Reddi AH, Amédée J (December 1997). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochemical and Biophysical Research Communications. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787.
Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V, Lyons KM (January 2001). "Bone morphogenetic protein-3 is a negative regulator of bone density". Nature Genetics. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004. S2CID 205097212.
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (October 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
Kloen P, Di Paola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ (September 2003). "BMP signaling components are expressed in human fracture callus". Bone. 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.
Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC (September 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy. 11 (17): 1312–20. doi:10.1038/sj.gt.3302298. PMID 15269709.
Chen AL, Fang C, Liu C, Leslie MP, Chang E, Di Cesare PE (November 2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". Journal of Orthopaedic Research. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196. S2CID 11544281.

پیوند به بیرون

مکان ژنوم BMP3 انسانی و صفحهٔ جزئیات ژنی BMP3 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".

[Rasmussen_2016-5] Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (June 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585. S2CID 25724654.

[6] Kormi, Seyed Mohammad Amin; Ardehkhani, Shima; Kerachian, Mohammad Amin (November 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.