اکتینین آلفا ۴

ACTN4
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WLX, 1YDI, 2R0O
معین‌کننده‌ها
نام‌های دیگر	ACTN4, ACTININ-4, FSGS, FSGS1, Actinin alpha 4
شناسه‌های بیرونی	OMIM: 604638 MGI: 1890773 HomoloGene: 55857 GeneCards: ACTN4
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[1]
End	28,962,340 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• metal ion binding; • calcium ion binding; • actin binding; • GO:0032403 protein-containing complex binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • protein homodimerization activity; • protein N-terminus binding; • nucleoside binding; • ion channel binding; • nuclear receptor coactivator activity; • integrin binding; • retinoic acid receptor binding; • chromatin DNA binding; • GO:0001948 پیوند پروتئینی; • actin filament binding; • RNA binding; • GO:0001105 transcription coactivator activity;
ترکیبات سلولی	• extracellular exosome; • extracellular region; • brush border; • پای کاذب; • سیتوپلاسم; • actin cytoskeleton; • پیوند میان‌یاخته‌ای; • هسته یاخته; • stress fiber; • cell-cell junction; • neuron projection; • focal adhesion; • platelet alpha granule lumen; • intracellular anatomical structure; • Z disc; • perinuclear region of cytoplasm; • cortical cytoskeleton; • extracellular space; • سیتوزول; • nuclear body; • اسکلت سلولی; • protein-containing complex; • ribonucleoprotein complex;
فرایند زیستی	• response to hypoxia; • vesicle transport along actin filament; • actin filament bundle assembly; • positive regulation of NIK/NF-kappaB signaling; • regulation of apoptotic process; • positive regulation of cell migration; • negative regulation of cellular component movement; • bicellular tight junction assembly; • positive regulation of sodium:proton antiporter activity; • protein localization to bicellular tight junction; • platelet degranulation; • positive regulation of pinocytosis; • retinoic acid receptor signaling pathway; • regulation of nucleic acid-templated transcription; • protein transport; • peroxisome proliferator activated receptor signaling pathway; • negative regulation of substrate adhesion-dependent cell spreading; • positive regulation of cellular component movement; • transport; • tumor necrosis factor-mediated signaling pathway; • positive regulation of nucleic acid-templated transcription;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	81
	60595
	ENSG00000130402; ENSG00000282844
	ENSMUSG00000054808
	O43707
	P57780
	NM_004924، XM_005259281، NM_001322033، XM_017027331 XM_006723406، NM_004924، XM_005259281، NM_001322033، XM_017027331
	XM_006540255، XM_006540257، NM_001360548، NM_001360549، NM_001360550 NM_021895، XM_006540255، XM_006540257، NM_001360548، NM_001360549، NM_001360550
	NP_004915، XP_005259338، XP_006723469، XP_016882820 NP_001308962، NP_004915، XP_005259338، XP_006723469، XP_016882820
	XP_006540318، XP_006540320، NP_001347477، NP_001347478، NP_001347479، XP_036009204، XP_036009205 NP_068695، XP_006540318، XP_006540320، NP_001347477، NP_001347478، NP_001347479، XP_036009204، XP_036009205
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

اکتینین آلفا ۴ (انگلیسی: Actinin alpha 4‎) یک پروتئین است که در انسان توسط ژن «ACTN4» کُدگذاری می‌شود.[4]

آلفا اکتینین‌ها متعلق به ابرخانوادهٔ اسپکترین هستند که از پروتئین‌های ساختار اسکلتی سلول محسوب می‌شوند.

جهش در این ژن با بروز نوعی خاص از بیماری کلیوی به نام «گلومرولونفروز موضعی ناحیه‌ای» در ارتباط است.[4]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000054808 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ACTN4 actinin, alpha 4".

مشارکت‌کنندگان ویکی‌پدیا. «Actinin alpha 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

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Yürüker B, Niggli V (1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network". J. Cell Sci. 101. ( Pt 2): 403–14. PMID 1629252.
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Nikolopoulos SN, Spengler BA, Kisselbach K, et al. (2000). "The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells". Oncogene. 19 (3): 380–6. doi:10.1038/sj.onc.1203310. PMID 10656685.
El-Husseini AE, Kwasnicka D, Yamada T, et al. (2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochem. Biophys. Res. Commun. 267 (3): 906–11. doi:10.1006/bbrc.1999.2045. PMID 10673389.
Kaplan JM, Kim SH, North KN, et al. (2000). "Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis". Nat. Genet. 24 (3): 251–6. doi:10.1038/73456. PMID 10700177.
Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. 275 (15): 11100–5. doi:10.1074/jbc.275.15.11100. PMID 10753915.
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Echchakir H, Mami-Chouaib F, Vergnon I, et al. (2001). "A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma". Cancer Res. 61 (10): 4078–83. PMID 11358829.
Xu F, Zhao R, Peng Y, et al. (2001). "Association of tyrosine phosphatase SHP-2 with F-actin at low cell densities". J. Biol. Chem. 276 (31): 29479–84. doi:10.1074/jbc.M104428200. PMID 11382784.
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Renoult C, Blondin L, Fattoum A, et al. (2002). "Binding of gelsolin domain 2 to actin. An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin". Eur. J. Biochem. 268 (23): 6165–75. doi:10.1046/j.0014-2956.2001.02574.x. PMID 11733011.
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پیوند به بیرون

مکان ژنوم ACTN4 انسانی و صفحهٔ جزئیات ژنی ACTN4 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000054808 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: ACTN4 actinin, alpha 4".