CD63

مجموعه تمایزی ۶۳ (به انگلیسی: CD63) یک پروتئین است که در انسان توسط ژن «CD63» کُدگذاری می‌شود.[1]

CD63 molecule
معین‌کننده‌ها
نام‌های دیگرocular melanoma-associated antigenmelanoma-associated antigen MLA1lysosome-associated membrane glycoprotein 3CD63 antigen (melanoma 1 antigen)OMA81Hlysosomal-associated membrane protein 3CD63LAMP-3melanoma-associated antigen ME491granulophysintetraspanin-30CD63 antigentspan-30Tetraspanin 30
شناسه‌های بیرونیGeneCards:
الگوی گسترش RNA
More reference expression data
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

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آنسامبل

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یونی‌پروت

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RefSeq (mRNA)

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RefSeq (پروتئین)

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موقعیت (UCSC)n/an/a
جستجوی PubMedn/an/a
ویکی‌داده
مشاهده/ویرایش Human

این پروتئین بیشتر بر روی پوستهٔ درون‌سلولی ریزدانه‌ها یافت یم شود، اما بر روی سطح یاخته‌ها نیز ممکن است دیده شود.

فقدان این پروتئین ممکن است سبب بروز «سندرم هرمانسکی-پودلاک» شود. فقدان ژن «CD63» با پیشرفت تومورهای سرطانی مرتبط است.

پروتئین CD63 یک نشانگر زیستی خوب برای فعال‌شدگی بازوفیل‌ها در جریان آلرژی‌های مرتبط با پادتن ای است. نام این آزمایش «تست فعال‌شدگی بازوفیل» (BAT) است.

پروتئین CD63 با مولکول‌های CD117[2] و CD82[3] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

پانویس
  1. "Entrez Gene: CD63 CD63 molecule".
  2. Anzai N, Lee Y, Youn BS, Fukuda S, Kim YJ, Mantel C, Akashi M, Broxmeyer HE (June 2002). "C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors". Blood. 99 (12): 4413–21. doi:10.1182/blood.V99.12.4413. PMID 12036870.
  3. Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. PMID 9759843.

پیوند به بیرون

برای مطالعهٔ بیشتر
  • Mal G (2012). Investigation of cellular functions of tetraspanin CD63. Germany: LAP LAMBERT Academic Publishing (LAP), GmbH & Co. ISBN 978-3-659-18758-2.
  • Horejsí V, Vlcek C (August 1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Letters. 288 (1–2): 1–4. doi:10.1016/0014-5793(91)80988-F. PMID 1879540.
  • Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. PMID 11739647.
  • Wang MX, Earley JJ, Shields JA, Donoso LA (March 1992). "An ocular melanoma-associated antigen. Molecular characterization". Archives of Ophthalmology. 110 (3): 399–404. doi:10.1001/archopht.1992.01080150097036. PMID 1339263.
  • Hotta H, Miyamoto H, Hara I, Takahashi N, Homma M (May 1992). "Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences". Biochemical and Biophysical Research Communications. 185 (1): 436–42. doi:10.1016/S0006-291X(05)81004-6. PMID 1599482.
  • Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC (February 1991). "CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells". The Journal of Biological Chemistry. 266 (5): 3239–45. PMID 1993697.
  • Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (September 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA and Cell Biology. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. hdl:11858/00-001M-0000-0013-0D4C-0. PMID 2171551.
  • Hotta H, Takahashi N, Homma M (December 1989). "Transcriptional enhancement of the human gene encoding for a melanoma-associated antigen (ME491) in association with malignant transformation". Japanese Journal of Cancer Research. 80 (12): 1186–91. doi:10.1111/j.1349-7006.1989.tb01653.x. PMC 5917931. PMID 2516848.
  • Hotta H, Ross AH, Huebner K, Isobe M, Wendeborn S, Chao MV, Ricciardi RP, Tsujimoto Y, Croce CM, Koprowski H (June 1988). "Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression". Cancer Research. 48 (11): 2955–62. PMID 3365686.
  • Ross AH, Dietzschold B, Jackson DM, Earley JJ, Ghrist BD, Atkinson B, Koprowski H (November 1985). "Isolation and amino terminal sequencing of a novel melanoma-associated antigen". Archives of Biochemistry and Biophysics. 242 (2): 540–8. doi:10.1016/0003-9861(85)90241-3. PMID 4062294.
  • Berditchevski F, Bazzoni G, Hemler ME (July 1995). "Specific association of CD63 with the VLA-3 and VLA-6 integrins". The Journal of Biological Chemistry. 270 (30): 17784–90. doi:10.1074/jbc.270.30.17784. PMID 7629079.
  • Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard JM (April 1993). "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin". The Journal of Clinical Investigation. 91 (4): 1775–82. doi:10.1172/JCI116388. PMC 288158. PMID 7682577.
  • Radford KJ, Thorne RF, Hersey P (May 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochemical and Biophysical Research Communications. 222 (1): 13–8. doi:10.1006/bbrc.1996.0690. PMID 8630057.
  • Gwynn B, Eicher EM, Peters LL (July 1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome". Genomics. 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157.
  • Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME (September 1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology. 157 (5): 2039–47. PMID 8757325.
  • Skubitz KM, Campbell KD, Iida J, Skubitz AP (October 1996). "CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils". Journal of Immunology. 157 (8): 3617–26. PMID 8871662.
  • Berditchevski F, Tolias KF, Wong K, Carpenter CL, Hemler ME (January 1997). "A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase". The Journal of Biological Chemistry. 272 (5): 2595–8. doi:10.1074/jbc.272.5.2595. PMID 9006891.
  • Sincock PM, Mayrhofer G, Ashman LK (April 1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". The Journal of Histochemistry and Cytochemistry. 45 (4): 515–25. doi:10.1177/002215549704500404. PMID 9111230.
  • Berditchevski F, Chang S, Bodorova J, Hemler ME (November 1997). "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6". The Journal of Biological Chemistry. 272 (46): 29174–80. doi:10.1074/jbc.272.46.29174. PMID 9360995.
  • Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
در ویکی‌انبار پرونده‌هایی دربارهٔ CD63 موجود است.
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