PFKL

Phosphofructokinase, liver type
معین‌کننده‌ها
نام‌های دیگر	phosphofructo-1-kinase isozyme B6-phosphofructokinaseliver typePFK-Bphosphohexokinaseliver-type 1-phosphofructokinasePFKLATP-dependent 6-phosphofructokinaseliver type6-phosphofructokinase type B
شناسه‌های بیرونی	GeneCards:
هم‌ساخت‌شناسی
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	ویکی‌داده
مشاهده/ویرایش Human

۶-فسفوفروکتوکیناز، کبد (انگلیسی: 6-phosphofructokinase, liver type‎) یک آنزیم است که در انسان توسط ژن «PFKL» واقع بر کروموزوم ۲۱ کُدگذاری می‌شود.[1] آنزیم‌های گروه فسفوفروکتوکیناز، به‌طور غیرقابل بازگشت، موجب تبدیل فروکتوز ۶-فسفات به فروکتوز ۱٬۶-بیس‌فسفات شده و یکی از آنزیم‌های تنظیمی مهم در فرایند گلیکولیز محسوب می‌شوند.

افزایش ژن ژن PFKL با نشانگان داون در ارتباط است.

جستارهای وابسته

PFKP

منابع

"Entrez Gene: PFKL phosphofructokinase, liver".

مشارکت‌کنندگان ویکی‌پدیا. «PFKL». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۱ اکتبر ۲۰۱۸.

بیشتر بخوانید

Kahn A, Meienhofer MC, Cottreau D, Lagrange JL, Dreyfus JC (April 1979). "Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues". Human Genetics. 48 (1): 93–108. doi:10.1007/bf00273280. PMID 156693.
Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing error frequency in the DNA sequence databases". DNA Sequence. 2 (6): 343–6. doi:10.3109/10425179209020815. PMID 1446073.
Wang D, Fang H, Cantor CR, Smith CL (April 1992). "A contiguous Not I restriction map of band q22.3 of human chromosome 21". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3222–6. doi:10.1073/pnas.89.8.3222. PMC 48838. PMID 1565613.
Elson A, Levanon D, Brandeis M, Dafni N, Bernstein Y, Danciger E, Groner Y (May 1990). "The structure of the human liver-type phosphofructokinase gene". Genomics. 7 (1): 47–56. doi:10.1016/0888-7543(90)90517-X. PMID 2139864.
Levanon D, Danciger E, Dafni N, Bernstein Y, Elson A, Moens W, Brandeis M, Groner Y (December 1989). "The primary structure of human liver type phosphofructokinase and its comparison with other types of PFK". Dna. 8 (10): 733–43. doi:10.1089/dna.1989.8.733. PMID 2533063.
Van Keuren M, Drabkin H, Hart I, Harker D, Patterson D, Vora S (September 1986). "Regional assignment of human liver-type 6-phosphofructokinase to chromosome 21q22.3 by using somatic cell hybrids and a monoclonal anti-L antibody". Human Genetics. 74 (1): 34–40. doi:10.1007/bf00278782. PMID 2944814.
Levanon D, Danciger E, Dafni N, Groner Y (November 1986). "Genomic clones of the human liver-type phosphofructokinase". Biochemical and Biophysical Research Communications. 141 (1): 374–80. doi:10.1016/S0006-291X(86)80379-5. PMID 2948503.
Vora S, Davidson M, Seaman C, Miranda AF, Noble NA, Tanaka KR, Frenkel EP, Dimauro S (December 1983). "Heterogeneity of the molecular lesions in inherited phosphofructokinase deficiency". The Journal of Clinical Investigation. 72 (6): 1995–2006. doi:10.1172/JCI111164. PMC 437040. PMID 6227635.
Vora S, Seaman C, Durham S, Piomelli S (Jan 1980). "Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system". Proceedings of the National Academy of Sciences of the United States of America. 77 (1): 62–6. doi:10.1073/pnas.77.1.62. PMC 348208. PMID 6444721.
Koster JF, Slee RG, Van Berkel TJ (April 1980). "Isoenzymes of human phosphofructokinase". Clinica Chimica Acta; International Journal of Clinical Chemistry. 103 (2): 169–73. doi:10.1016/0009-8981(80)90210-7. PMID 6445244.
Vora S, Francke U (June 1981). "Assignment of the human gene for liver-type 6-phosphofructokinase isozyme (PFKL) to chromosome 21 by using somatic cell hybrids and monoclonal anti-L antibody". Proceedings of the National Academy of Sciences of the United States of America. 78 (6): 3738–42. doi:10.1073/pnas.78.6.3738. PMC 319647. PMID 6455664.
Zeitschel U, Bigl M, Eschrich K, Bigl V (December 1996). "Cellular distribution of 6-phosphofructo-1-kinase isoenzymes in rat brain". Journal of Neurochemistry. 67 (6): 2573–80. doi:10.1046/j.1471-4159.1996.67062573.x. PMID 8931492.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN (September 2003). "Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing". The Journal of Biological Chemistry. 278 (37): 35325–36. doi:10.1074/jbc.M305191200. PMID 12840015.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.

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[entrez-1] "Entrez Gene: PFKL phosphofructokinase, liver".