Lck

تیروزین پروتئین کینازِ اختصاصیِ لنفوسیت‌ها (انگلیسی: Lymphocyte-specific protein tyrosine kinase‎) یک پروتئین به وزن مولکولی ۵۶ کیلو دالتون است که در درون لنفوسیت‌های دستگاه ایمنی یافت می‌شود. این پروتئین یک تیروزین کیناز است که موجب فسفرگیری ریشه‌های تیروزینی برخی پروتئین‌ها می‌گردد که در مسیرهای سیگنالینگ (علامت‌دهی) درون‌سلولی نقش دارند.

LCK
ساختارهای موجود
PDBOrtholog search: PDBe RCSB
معین‌کننده‌ها
نام‌های دیگرLCK, LCK proto-oncogene, Src family tyrosine kinase, IMD22, LSK, YT16, p56lck, pp58lck
شناسه‌های بیرونیOMIM: 153390 MGI: 96756 HomoloGene: 3911 GeneCards: LCK
الگوی گسترش RNA


More reference expression data
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

3932

16818

آنسامبل

ENSG00000182866

ENSMUSG00000000409

یونی‌پروت

P06239

P06240

RefSeq (mRNA)

NM_005356، XM_011541453، NM_001330468، XM_024447046، XM_024447047 NM_001042771، NM_005356، XM_011541453، NM_001330468، XM_024447046، XM_024447047

NM_001162433، NM_010693، XM_006502818، XM_030253275، XM_030253276 NM_001162432، NM_001162433، NM_010693، XM_006502818، XM_030253275، XM_030253276

RefSeq (پروتئین)

NP_001317397، NP_005347، XP_011539755، XP_024302814، XP_024302815 NP_001036236، NP_001317397، NP_005347، XP_011539755، XP_024302814، XP_024302815

NP_001155905، NP_034823، XP_006502881، XP_030109135 NP_001155904، NP_001155905، NP_034823، XP_006502881، XP_030109135

موقعیت (UCSC)n/aChr : 129.55 – 129.57 Mb
جستجوی PubMed[2][3]
ویکی‌داده
مشاهده/ویرایش HumanView/Edit Mouse

بیشترین میزان پروتئین Lck در لنفوسیت تی، به‌ویژه در لنفوسیت تی کمک‌کننده و لنفوسیت تی کشنده یافت می‌شود.[4][5]

این پروتئین در فسفرگیری دومین SH2، پروتئین کیناز سی، CD3، PI-3K و RASA1 نقش دارد.

پروتئین Lck با DLG1[6] و PTPRC[7][8] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

منابع
  1. GRCm38: Ensembl release 89: ENSMUSG00000000409 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF (July 1988). "The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 85 (14): 5190–4. doi:10.1073/pnas.85.14.5190. PMC 281714. PMID 2455897.
  5. Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (May 1989). "The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex". Proceedings of the National Academy of Sciences of the United States of America. 86 (9): 3277–81. doi:10.1073/pnas.86.9.3277. PMC 287114. PMID 2470098.
  6. Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH (October 1997). "Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes". The Journal of Biological Chemistry. 272 (43): 26899–904. doi:10.1074/jbc.272.43.26899. PMID 9341123.
  7. Koretzky GA, Kohmetscher M, Ross S (April 1993). "CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line". The Journal of Biological Chemistry. 268 (12): 8958–64. PMID 8473339.
  8. Ng DH, Watts JD, Aebersold R, Johnson P (January 1996). "Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro". The Journal of Biological Chemistry. 271 (3): 1295–300. doi:10.1074/jbc.271.3.1295. PMID 8576115.

برای مطالعهٔ بیشتر
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  • Goldmann WH (2003). "p56(lck) Controls phosphorylation of filamin (ABP-280) and regulates focal adhesion kinase (pp125(FAK))". Cell Biology International. 26 (6): 567–71. doi:10.1006/cbir.2002.0900. PMID 12171035.
  • Mustelin T, Taskén K (April 2003). "Positive and negative regulation of T-cell activation through kinases and phosphatases". The Biochemical Journal. 371 (Pt 1): 15–27. doi:10.1042/BJ20021637. PMC 1223257. PMID 12485116.
  • Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B (February 2003). "The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation". Immunological Reviews. 191: 107–18. doi:10.1034/j.1600-065X.2003.00015.x. PMID 12614355.
  • Summy JM, Gallick GE (December 2003). "Src family kinases in tumor progression and metastasis". Cancer Metastasis Reviews. 22 (4): 337–58. doi:10.1023/A:1023772912750. PMID 12884910.
  • Leavitt SA, SchOn A, Klein JC, Manjappara U, Chaiken IM, Freire E (February 2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm". Current Protein & Peptide Science. 5 (1): 1–8. doi:10.2174/1389203043486955. PMID 14965316.
  • Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (April 2004). "HIV/SIV escape from immune surveillance: focus on Nef". Current HIV Research. 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178.
  • Palacios EH, Weiss A (October 2004). "Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation". Oncogene. 23 (48): 7990–8000. doi:10.1038/sj.onc.1208074. PMID 15489916.
  • Joseph AM, Kumar M, Mitra D (January 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
  • Levinson AD, Oppermann H, Levintow L, Varmus HE, Bishop JM (October 1978). "Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein". Cell. 15 (2): 561–72. doi:10.1016/0092-8674(78)90024-7. PMID 214242.
  • Thomas PM, Samelson LE (June 1992). "The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells". The Journal of Biological Chemistry. 267 (17): 12317–22. PMID 1351058.
  • Shenoy-Scaria AM, Kwong J, Fujita T, Olszowy MW, Shaw AS, Lublin DM (December 1992). "Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1". Journal of Immunology. 149 (11): 3535–41. PMID 1385527.
  • Weber JR, Bell GM, Han MY, Pawson T, Imboden JB (August 1992). "Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor". The Journal of Experimental Medicine. 176 (2): 373–9. doi:10.1084/jem.176.2.373. PMC 2119313. PMID 1500851.
  • Cefai D, Ferrer M, Serpente N, Idziorek T, Dautry-Varsat A, Debre P, Bismuth G (July 1992). "Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation". Journal of Immunology. 149 (1): 285–94. PMID 1535086.
  • Soula M, Fagard R, Fischer S (February 1992). "Interaction of human immunodeficiency virus glycoprotein 160 with CD4 in Jurkat cells increases p56lck autophosphorylation and kinase activity". International Immunology. 4 (2): 295–9. doi:10.1093/intimm/4.2.295. PMID 1535787.
  • Crise B, Rose JK (April 1992). "Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum". Journal of Virology. 66 (4): 2296–301. PMC 289024. PMID 1548763.
  • Molina TJ, Kishihara K, Siderovski DP, van Ewijk W, Narendran A, Timms E, Wakeham A, Paige CJ, Hartmann KU, Veillette A (May 1992). "Profound block in thymocyte development in mice lacking p56lck". Nature. 357 (6374): 161–4. doi:10.1038/357161a0. PMID 1579166.
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  • Torigoe T, O'Connor R, Santoli D, Reed JC (August 1992). "Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines". Blood. 80 (3): 617–24. PMID 1638019.

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