KLRB1
گیرندهٔ شبه لکتینی سلول کُشنده، خانوادهٔ B عضو ۱ (انگلیسی: Killer cell lectin-like receptor subfamily B, member 1) که با نام‌های NK1.1 و CD161 هم شناخته می‌شوند، یک پروتئین است که در انسان توسط ژن «KLRB1» کُدگذاری می‌شود.[4]
| KLRB1 | |||||||||||||||||||||||||
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| معین‌کننده‌ها | |||||||||||||||||||||||||
| نام‌های دیگر | KLRB1, CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A, killer cell lectin like receptor B1 | ||||||||||||||||||||||||
| شناسه‌های بیرونی | OMIM: 602890 MGI: 107540 HomoloGene: 84369 GeneCards: KLRB1 | ||||||||||||||||||||||||
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| هم‌ساخت‌شناسی | |||||||||||||||||||||||||
| گونه‌ها | انسان | موش | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
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| یونی‌پروت | |||||||||||||||||||||||||
| RefSeq (mRNA) | |||||||||||||||||||||||||
| RefSeq (پروتئین) | |||||||||||||||||||||||||
| موقعیت (UCSC) | n/a | Chr : 128.61 – 128.62 Mb | |||||||||||||||||||||||
| جستجوی PubMed | [2] | [3] | |||||||||||||||||||||||
| ویکی‌داده | |||||||||||||||||||||||||
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سلول‌های کشنده طبیعی، لنفوسیت‌هایی هستند که با ترشح سیتوکین‌ها پس از تحریک سیستم ایمنی بدن، کشتار سلولی را سبب می‌شود. چندین ژن از خانوادهٔ بزرگ لکتین‌های نوع سی و از جمله ژن‌ها و گلیکوپروتئین‌های KLRA1 در جوندگان در سلول‌های کشنده طبیعی بیان می‌شود و در تنظیم عملکرد آنان نقش دارند.
منابع
- GRCm38: Ensembl release 89: ENSMUSG00000030361 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: KLRB1 killer cell lectin-like receptor subfamily B, member 1".
- مشارکت‌کنندگان ویکی‌پدیا. «KLRB1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۹ دسامبر ۲۰۱۹.
برای مطالعهٔ بیشتر
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- Lanier LL, Chang C, Phillips JH (September 1994). "Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes". Journal of Immunology. 153 (6): 2417–28. PMID 8077657.
- Poggi A, Costa P, Morelli L, Cantoni C, Pella N, Spada F, Biassoni R, Nanni L, Revello V, Tomasello E, Mingari MC, Moretta A, Moretta L (June 1996). "Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity". European Journal of Immunology. 26 (6): 1266–72. doi:10.1002/eji.1830260613. PMID 8647203.
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