UGT1A1

UGT1A1
معین‌کننده‌ها
نام‌های دیگر	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A, UDP glucuronosyltransferase family 1 member A1
شناسه‌های بیرونی	OMIM: 191740 MGI: 98898 HomoloGene: 128034 GeneCards: UGT1A1
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[1]
End	88,218,997 bp[1]
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • GO:0048551 enzyme inhibitor activity; • retinoic acid binding; • transferase activity, transferring hexosyl groups; • protein homodimerization activity; • transferase activity, transferring glycosyl groups; • steroid binding; • protein heterodimerization activity; • enzyme binding; • glucuronosyltransferase activity; • UDP-glycosyltransferase activity;
ترکیبات سلولی	• integral component of membrane; • endoplasmic reticulum membrane; • membrane; • intracellular membrane-bounded organelle; • integral component of plasma membrane; • cytochrome complex; • endoplasmic reticulum chaperone complex; • شبکه آندوپلاسمی;
فرایند زیستی	• steroid metabolic process; • response to organic cyclic compound; • cellular response to ethanol; • estrogen metabolic process; • response to nutrient; • negative regulation of steroid metabolic process; • bilirubin conjugation; • response to steroid hormone; • response to glucocorticoid; • retinoic acid metabolic process; • negative regulation of cellular glucuronidation; • response to organic substance; • response to lipopolysaccharide; • cellular response to hormone stimulus; • چرخه تجزیه هم; • cellular response to glucocorticoid stimulus; • acute-phase response; • heterocycle metabolic process; • animal organ regeneration; • drug metabolic process; • response to starvation; • flavone metabolic process; • liver development; • دگرگشت; • negative regulation of glucuronosyltransferase activity; • response to ethanol; • negative regulation of fatty acid metabolic process; • response to drug; • biphenyl catabolic process; • cellular response to estradiol stimulus; • flavonoid glucuronidation; • گلوکورونیداسیون; • xenobiotic glucuronidation; • cellular response to xenobiotic stimulus; • GO:0048553 negative regulation of catalytic activity;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	54658
	394436
	ENSG00000241635
	ENSMUSG00000089960
	P22309
	Q63886
	NM_000463
	NM_201645
	NP_000454
	NP_964007
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

اوریدین دی‌فسفات-گلوکورونوزیل‌ترانسفراز ۱–۱ (انگلیسی: UDP-glucuronosyltransferase 1-1‎) که با نام «UGT-1A» هم شناخته می‌شود، نام آنزیمی است که در انسان توسط ژن «UGT1A1» کُد می‌شود.[4][5]

این آنزیم در مسیر گلوکورونیداسیون شرکت دارد و ملکول‌های لیپوفیلیک کوچک نظیر استروئیدها، بیلی‌روبین، هورمونها و داروها را به متابولیتهای محلول در آب و قابل دفع، تبدیل می‌کند.[6]

جستارهای وابسته

زردی نوزادان

منابع

GRCm38: Ensembl release 89: ENSMUSG00000089960 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
Strassburg CP, Manns MP, Tukey RH (April 1998). "Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8". J. Biol. Chem. 273 (15): 8719–26. doi:10.1074/jbc.273.15.8719. PMID 9535849.
"Entrez Gene: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1".

مشارکت‌کنندگان ویکی‌پدیا. «UDP glucuronosyltransferase 1 family, polypeptide A1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۸ نوامبر ۲۰۱۷.

پیوند به بیرون

UGT1A1 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000089960 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9295054-4] Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.

[pmid9535849-5] Strassburg CP, Manns MP, Tukey RH (April 1998). "Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8". J. Biol. Chem. 273 (15): 8719–26. doi:10.1074/jbc.273.15.8719. PMID 9535849.

[nlm54658-6] "Entrez Gene: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1".