STAT5B

STAT5B
معین‌کننده‌ها
نام‌های دیگر	STAT5B, STAT5, signal transducer and activator of transcription 5B, GHISID2
شناسه‌های بیرونی	OMIM: 604260 MGI: 103035 HomoloGene: 55718 GeneCards: STAT5B
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[1]
End	100,850,724 bp[1]
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• signal transducer activity; • glucocorticoid receptor binding; • protein dimerization activity; • chromatin binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001948 پیوند پروتئینی; • protein tyrosine kinase activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	• نوکلئوپلاسم; • سیتوپلاسم; • هسته یاخته; • سیتوزول;
فرایند زیستی	• positive regulation of natural killer cell differentiation; • positive regulation of natural killer cell mediated cytotoxicity; • regulation of steroid metabolic process; • creatinine metabolic process; • T cell differentiation in thymus; • female pregnancy; • cellular response to hormone stimulus; • positive regulation of activated T cell proliferation; • progesterone metabolic process; • receptor signaling pathway via JAK-STAT; • negative regulation of apoptotic process; • Peyer's patch development; • transcription, DNA-templated; • ورارسانی پیام; • cellular response to growth factor stimulus; • natural killer cell differentiation; • response to interleukin-4; • sex differentiation; • valine metabolic process; • positive regulation of B cell differentiation; • T cell homeostasis; • creatine metabolic process; • cellular response to epidermal growth factor stimulus; • response to estradiol; • positive regulation of inflammatory response; • regulation of transcription by RNA polymerase II; • mast cell migration; • positive regulation of mitotic cell cycle; • lipid storage; • development of secondary female sexual characteristics; • Synthesis saturated fatty acids by metabolites; • taurine metabolic process; • succinate metabolic process; • positive regulation of gamma-delta T cell differentiation; • positive regulation of lymphocyte differentiation; • regulation of multicellular organism growth; • citrate metabolic process; • positive regulation of cell population proliferation; • oxaloacetate metabolic process; • regulation of epithelial cell differentiation; • positive regulation of natural killer cell proliferation; • development of secondary male sexual characteristics; • positive regulation of multicellular organism growth; • regulation of transcription, DNA-templated; • allantoin metabolic process; • positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • luteinization; • isoleucine metabolic process; • negative regulation of erythrocyte differentiation; • lactation; • response to interleukin-15; • regulation of cell adhesion; • 2-oxoglutarate metabolic process; • response to interleukin-2; • growth hormone receptor signaling pathway via JAK-STAT; • positive regulation of erythrocyte differentiation; • peptidyl-tyrosine phosphorylation; • interleukin-7-mediated signaling pathway; • interleukin-15-mediated signaling pathway; • cytokine-mediated signaling pathway; • interleukin-2-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • defense response; • regulation of cell population proliferation; • response to peptide hormone;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6777
	20851
	ENSG00000173757
	ENSMUSG00000020919
	P51692
	P42232
	NM_012448، XM_017024977، XM_024450897، XM_024450898 XM_005257626، NM_012448، XM_017024977، XM_024450897، XM_024450898
	NM_011489، XM_006532723، NM_001362682، XM_030245749 NM_001113563، NM_011489، XM_006532723، NM_001362682، XM_030245749
	XP_005257683، XP_016880466، XP_024306665، XP_024306666 NP_036580، XP_005257683، XP_016880466، XP_024306665، XP_024306666
	NP_035619، NP_001349611 NP_001107035، NP_035619، NP_001349611
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

تَرارسانندهٔ پیام و فعال‌کنندهٔ رونویسی ۵ بی (انگلیسی: Signal transducer and activator of transcription 5B‎) یک پروتئین است که در انسان توسط ژن «STAT5B» کُدگذاری می‌شود.[4]

این مولکول عضوی از خانوادهٔ STAT است که همگی فاکتور رونویسی هستند. در پاسخ به سیتوکین‌ها، اعضای خانوادهٔ STAT فسفریله شده و به هستهٔ سلول می‌روند و در آنجا، نقش یک فعال‌کنندهٔ رونویسی ژنتیکی را ایفا می‌کنند.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000020919 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID 8631883.

مشارکت‌کنندگان ویکی‌پدیا. «STAT5B». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر

Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene. 285 (1–2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020919 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8631883-4] Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID 8631883.