SKP1A

SKP1
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FQV, 1FS1, 1FS2, 1LDK, 1P22, 2ASS, 2AST, 2E31, 2E32, 2OVP, 2OVQ, 2OVR, 3L2O, 3WSO, 4I6J, 5IBK
معین‌کننده‌ها
نام‌های دیگر	SKP1, EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A, S-phase kinase-associated protein 1, S-phase kinase associated protein 1
شناسه‌های بیرونی	OMIM: 601434 MGI: 103575 HomoloGene: 38775 GeneCards: SKP1
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[1]
End	52,246,858 bp[1]
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• cullin family protein binding; • beta-catenin binding; • GO:1904264، GO:1904822، GO:0090622، GO:0090302 ubiquitin protein ligase activity; • GO:0001948 پیوند پروتئینی; • ubiquitin-protein transferase activity; • protein domain specific binding;
ترکیبات سلولی	• سیتوپلاسم; • نوکلئوپلاسم; • PcG protein complex; • هسته یاخته; • سیتوزول; • SCF ubiquitin ligase complex; • Cul7-RING ubiquitin ligase complex; • میان‌تن;
فرایند زیستی	• ubiquitin-dependent protein catabolic process; • histone H2A monoubiquitination; • NIK/NF-kappaB signaling; • G2/M transition of mitotic cell cycle; • stress-activated MAPK cascade; • protein ubiquitination; • protein polyubiquitination; • Wnt signaling pathway; • SCF complex assembly; • negative regulation of G2/M transition of mitotic cell cycle; • maintenance of protein location in nucleus; • cellular iron ion homeostasis; • پیرایش پسارونویسی; • interleukin-1-mediated signaling pathway; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • GO:0022415 viral process; • regulation of mitotic cell cycle phase transition; • stimulatory C-type lectin receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • T cell receptor signaling pathway;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6500
	21402
	ENSG00000113558
	ENSMUSG00000036309
	P63208
	Q9WTX5
	NM_006930 NM_170679، NM_006930
	XM_006532786 NM_011543، XM_006532786
	NP_733779 NP_008861، NP_733779
	XP_006532849، XP_036012398 NP_035673، XP_006532849، XP_036012398
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین ۱ مرتبط با کیناز مرحله اس (انگلیسی: S-phase kinase-associated protein 1‎) یک پروتئین است که در انسان توسط ژن «SKP1» کُدگذاری می‌شود.[4][5][6]

این مولکول با پروتئین‌های گوناگونی چون FBXO5[7] تعامل پروتئین-پروتئین دارد.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000036309 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Zhang H, Kobayashi R, Galaktionov K, Beach D (October 1995). "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase". Cell. 82 (6): 915–25. doi:10.1016/0092-8674(95)90271-6. PMID 7553852.
Demetrick DJ, Zhang H, Beach DH (July 1996). "Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2)". Cytogenet Cell Genet. 73 (1–2): 104–7. doi:10.1159/000134318. PMID 8646875.
"Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)".
Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

مشارکت‌کنندگان ویکی‌پدیا. «SKP1A». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۳ مارس ۲۰۱۹.

برای مطالعهٔ بیشتر

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Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000036309 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7553852-4] Zhang H, Kobayashi R, Galaktionov K, Beach D (October 1995). "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase". Cell. 82 (6): 915–25. doi:10.1016/0092-8674(95)90271-6. PMID 7553852.

[pmid8646875-5] Demetrick DJ, Zhang H, Beach DH (July 1996). "Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2)". Cytogenet Cell Genet. 73 (1–2): 104–7. doi:10.1159/000134318. PMID 8646875.

[entrez-6] "Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)".

[pmid10531035-7] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.