REG3G

REG3G
معین‌کننده‌ها
نام‌های دیگر	REG3G, LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429, regenerating family member 3 gamma
شناسه‌های بیرونی	OMIM: 609933 MGI: 109406 HomoloGene: 128216 GeneCards: REG3G
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[1]
End	78,468,872 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• carbohydrate binding; • peptidoglycan binding; • oligosaccharide binding; • transmembrane signaling receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • extracellular region; • extracellular space;
فرایند زیستی	• positive regulation of wound healing; • positive regulation of keratinocyte proliferation; • negative regulation of keratinocyte differentiation; • inflammatory response; • acute-phase response; • MyD88-dependent toll-like receptor signaling pathway; • GO:0051637 defense response to Gram-positive bacterium; • antimicrobial humoral response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • positive regulation of cell population proliferation; • response to peptide hormone; • cell wall disruption in other organism;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	130120
	19695
	ENSG00000143954
	ENSMUSG00000030017
	Q6UW15
	O09049
	NM_001008387، NM_001270040، NM_198448، XM_024452693، XM_024452694 XM_005264135، NM_001008387، NM_001270040، NM_198448، XM_024452693، XM_024452694
	NM_011260
	NP_001256969، NP_940850، XP_005264192، XP_024308461، XP_024308462 NP_001008388، NP_001256969، NP_940850، XP_005264192، XP_024308461، XP_024308462
	NP_035390
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین ۳ گاما بازسازی‌کنندهٔ مشتق از جزایر لوزالمعده (به انگلیسی: Regenerating islet-derived protein 3 gamma) یک پروتئین است که در انسان توسط ژن «REG3G» کُدگذاری می‌شود.[4][5][6][7]

یاخته‌های پانت روده‌ها، این پروتئین را از طریق تحریک تی‌ال‌آر (TLRs) توسط الگوی ملکولی وابسته به پاتوژن (PAMPs) می‌سازند. این مولکول با اتصال به دیوارهٔ پپتیدوگلیکانی، باکتری‌های گرم-مثبت را هدف قرار می‌دهد و یکی از چندین پپتید باکتری‌کُشی است که توسط یاخته‌های پانت ساخته می‌شود.[8]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000030017 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H (September 2004). "Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III". Gene. 340 (1): 161–70. doi:10.1016/j.gene.2004.06.010. PMID 15556304.
Laurine E, Manival X, Montgelard C, Bideau C, Bergé-Lefranc JL, Erard M, Verdier JM (March 2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication" (PDF). Biochim. Biophys. Acta. 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617.
"Entrez Gene: REG3G regenerating islet-derived 3 gamma".
Abreu MT (February 2010). "Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function". Nat. Rev. Immunol. 10 (2): 131–44. doi:10.1038/nri2707. PMID 20098461.

مشارکت‌کنندگان ویکی‌پدیا. «REG3G». در دانشنامهٔ ویکی‌پدیای انگلیسی.

برای مطالعهٔ بیشتر

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Laurine E, Manival X, Montgelard C, et al. (2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication". Biochim. Biophys. Acta. 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandl K, Plitas G, Schnabl B, DeMatteo RP, Pamer EG (2007). "MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection". J. Exp. Med. 204 (8): 900–1891. doi:10.1084/jem.20070563. PMC 2118673. PMID 17635956.

در ویکی‌انبار پرونده‌هایی دربارهٔ REG3G موجود است.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000030017 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12975309-4] Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

[pmid15556304-5] Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H (September 2004). "Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III". Gene. 340 (1): 161–70. doi:10.1016/j.gene.2004.06.010. PMID 15556304.

[pmid15777617-6] Laurine E, Manival X, Montgelard C, Bideau C, Bergé-Lefranc JL, Erard M, Verdier JM (March 2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication" (PDF). Biochim. Biophys. Acta. 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617.

[entrez-7] "Entrez Gene: REG3G regenerating islet-derived 3 gamma".

[pmid20098461-8] Abreu MT (February 2010). "Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function". Nat. Rev. Immunol. 10 (2): 131–44. doi:10.1038/nri2707. PMID 20098461.