REG1A

REG1A
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LIT, 1QDD
معین‌کننده‌ها
نام‌های دیگر	REG1A, ICRF, P19, PSP, PSPS, PSPS1, PTP, REG, regenerating family member 1 alpha
شناسه‌های بیرونی	OMIM: 167770 MGI: 97895 HomoloGene: 68282 GeneCards: REG1A
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[1]
End	78,428,667 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• carbohydrate binding; • growth factor activity; • transmembrane signaling receptor activity; • signaling receptor binding; • phosphatase binding; • protein phosphatase binding; • identical protein binding; • protein homodimerization activity; • peptidoglycan binding; • oligosaccharide binding;
ترکیبات سلولی	• extracellular region; • extracellular exosome; • extracellular space; • سیتوزول; • growth cone; • dendrite membrane; • neuronal cell body membrane; • protein-containing complex; • zymogen granule; • basal part of cell; • perinuclear region of cytoplasm;
فرایند زیستی	• positive regulation of cell population proliferation; • regulation of signaling receptor activity; • response to hypoxia; • midgut development; • negative regulation of cell population proliferation; • positive regulation of gene expression; • response to organic cyclic compound; • response to nutrient levels; • بهبود زخم; • response to peptide hormone; • cell wall disruption in other organism; • protein homooligomerization; • protein homotetramerization; • calcium ion homeostasis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • liver regeneration; • response to acetylsalicylate; • positive regulation of dendrite extension; • positive regulation of type B pancreatic cell proliferation; • positive regulation of acinar cell proliferation; • response to water-immersion restraint stress; • pancreas regeneration; • response to growth hormone-releasing hormone; • response to gastrin; • cellular response to chemokine; • cellular response to gastrin; • ورارسانی پیام;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5967
	19692
	ENSG00000115386
	ENSMUSG00000059654
	P05451
	P43137
	NM_002909
	NM_009042
	NP_002900
	NP_033068
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

لیتوستاتین-۱-آلفا (به انگلیسی: Lithostathine-1-alpha) یک پروتئین است که در انسان توسط ژن «REG1A» کُدگذاری می‌شود.[4][5][6]

این پروتئین که یکی از اعضای خانواده پروتئین‌های بازسازی‌کننده است، در لوزالمعده ترشح می‌شود و در بازسازی جزایر لانگرهانس و همچنین در بروز احتمالی دیابت و سنگ‌گری نقش دارد.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000059654 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (Jun 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem. 265 (13): 7432–9. PMID 2332435.
Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL (Aug 1993). "regeneration". Ann Hum Genet. 57 (Pt 1): 9–16. doi:10.1111/j.1469-1809.1993.tb00882.x. PMID 8333731.
"Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)".

مشارکت‌کنندگان ویکی‌پدیا. «REG1A». در دانشنامهٔ ویکی‌پدیای انگلیسی.

برای مطالعهٔ بیشتر

De Reggi M, Gharib B (2002). "Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions". Curr. Protein Pept. Sci. 2 (1): 19–42. doi:10.2174/1389203013381233. PMID 12369899.
Itoh T, Tsuzuki H, Katoh T, Teraoka H, Matsumoto K, Yoshida N, Terazono K, Watanabe T, Yonekura H, Yamamoto H (1990). "Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae". FEBS Lett. 272 (1–2): 85–8. doi:10.1016/0014-5793(90)80454-Q. PMID 2226837.
de la Monte SM, Ozturk M, Wands JR (1990). "Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain". J. Clin. Invest. 86 (3): 1004–13. doi:10.1172/JCI114762. PMC 296822. PMID 2394826.
De Caro AM, Adrich Z, Fournet B, Capon C, Bonicel JJ, De Caro JD, Rovery M (1989). "N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue". Biochim. Biophys. Acta. 994 (3): 281–4. doi:10.1016/0167-4838(89)90305-1. PMID 2493268.
Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC (1989). "Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis". J. Clin. Invest. 84 (1): 100–6. doi:10.1172/JCI114128. PMC 303958. PMID 2525567.
Stewart TA (1989). "The human reg gene encodes pancreatic stone protein". Biochem. J. 260 (2): 622–3. PMC 1138718. PMID 2764894.
Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H (1988). "A novel gene activated in regenerating islets". J. Biol. Chem. 263 (5): 2111–4. PMID 2963000.
Rouimi P, Bonicel J, Rovery M, De Caro A (1987). "Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein". FEBS Lett. 216 (2): 195–9. doi:10.1016/0014-5793(87)80688-9. PMID 3108036.
Rouimi P, de Caro J, Bonicel J, Rovery M, de Caro A (1988). "The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice". FEBS Lett. 229 (1): 171–4. doi:10.1016/0014-5793(88)80820-2. PMID 3345835.
Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De Caro A (1987). "Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein". Biochem. J. 238 (1): 227–32. PMC 1147119. PMID 3541906.
De Caro AM, Bonicel JJ, Rouimi P, De Caro JD, Sarles H, Rovery M (1987). "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice". Eur. J. Biochem. 168 (1): 201–7. doi:10.1111/j.1432-1033.1987.tb13405.x. PMID 3665916.
Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR (1986). "Isolation, characterization, and distribution of an unusual pancreatic human secretory protein". J. Clin. Invest. 76 (6): 2115–26. doi:10.1172/JCI112216. PMC 424321. PMID 3908481.
Perfetti R, Hawkins AL, Griffin CA, Egan JM, Zenilman ME, Shuldiner AR (1994). "Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12". Genomics. 20 (2): 305–7. doi:10.1006/geno.1994.1173. PMID 8020983.
Otonkoski T, Mally MI, Hayek A (1994). "Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells". Diabetes. 43 (9): 1164–6. doi:10.2337/diabetes.43.9.1164. PMID 8070617.
Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H (1994). "Isolation, structural determination and expression of a novel reg gene, human regI beta". Biochim. Biophys. Acta. 1217 (2): 199–202. doi:10.1016/0167-4781(94)90035-3. PMID 8110835.
Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn JC, Bergé-Lefranc JL (1993). "A gene homologous to the reg gene is expressed in the human pancreas". FEBS Lett. 327 (3): 289–93. doi:10.1016/0014-5793(93)81006-L. PMID 8348956.
Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC (1996). "Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation". EMBO J. 15 (11): 2678–84. PMC 450203. PMID 8654365.
Patard L, Stoven V, Gharib B, Bontems F, Lallemand JY, De Reggi M (1997). "What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy". Protein Eng. 9 (11): 949–57. doi:10.1093/protein/9.11.949. PMID 8961348.

در ویکی‌انبار پرونده‌هایی دربارهٔ REG1A موجود است.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000059654 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2332435-4] Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (Jun 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem. 265 (13): 7432–9. PMID 2332435.

[pmid8333731-5] Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL (Aug 1993). "regeneration". Ann Hum Genet. 57 (Pt 1): 9–16. doi:10.1111/j.1469-1809.1993.tb00882.x. PMID 8333731.

[entrez-6] "Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)".