MYD88

MYD88
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JS7, 2Z5V, 3MOP, 4DOM, 4EO7
معین‌کننده‌ها
نام‌های دیگر	MYD88, MYD88D, myeloid differentiation primary response 88, innate immune signal transduction adaptor, MYD88 innate immune signal transduction adaptor, IMD68
شناسه‌های بیرونی	OMIM: 602170 MGI: 108005 HomoloGene: 1849 GeneCards: MYD88
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[1]
End	119,341,411 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• death receptor binding; • GO:0001948 پیوند پروتئینی; • TIR domain binding; • identical protein binding; • protein self-association; • Toll-like receptor binding;
ترکیبات سلولی	• سیتوزول; • پوسته یاخته; • endosome membrane; • سیتوپلاسم; • هسته یاخته;
فرایند زیستی	• response to interleukin-1; • immune system process; • negative regulation of apoptotic process; • MyD88-dependent toll-like receptor signaling pathway; • toll-like receptor signaling pathway; • cell surface receptor signaling pathway; • cellular response to mechanical stimulus; • regulation of inflammatory response; • positive regulation of interleukin-6 production; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • toll-like receptor 9 signaling pathway; • positive regulation of interleukin-17 production; • inflammatory response; • 3'-UTR-mediated mRNA stabilization; • positive regulation of type I interferon production; • positive regulation of interleukin-23 production; • ورارسانی پیام; • GO:0051637 defense response to Gram-positive bacterium; • positive regulation of NF-kappaB transcription factor activity; • مرگ برنامه‌ریزی‌شده یاخته; • دستگاه ایمنی ذاتی; • type I interferon signaling pathway; • positive regulation of gene expression; • positive regulation of interleukin-8 production; • defense response to bacterium; • interleukin-1-mediated signaling pathway; • cellular response to oxidised low-density lipoprotein particle stimulus; • positive regulation of cytokine production involved in inflammatory response; • بیگانه‌خواری; • Toll signaling pathway;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4615
	17874
	ENSG00000172936
	ENSMUSG00000032508
	Q99836
	P22366
	NM_001172567، NM_001172568، NM_001172569، NM_002468، NM_001365876، NM_001365877، NM_001374787، NM_001374788، NR_164663 NM_001172566، NM_001172567، NM_001172568، NM_001172569، NM_002468، NM_001365876، NM_001365877، NM_001374787، NM_001374788، NR_164663
	NM_010851
	NP_001166038، NP_001166039، NP_001166040، NP_002459، NP_001352805، NP_001352806، NP_001361716، NP_001361717 NP_001166037، NP_001166038، NP_001166039، NP_001166040، NP_002459، NP_001352805، NP_001352806، NP_001361716، NP_001361717
	NP_034981
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین پاسخ اولیهٔ شماره ۸۸ تمایز میلوئید (انگلیسی: Myeloid differentiation primary response 88‎) مشهور به «MYD88» یک پروتئین است که در انسان توسط ژن «MYD88» کدگذاری می‌شود.[4][5]

برای بررسی این پروتئین از ارگانیسم‌های مدل از جمله موش‌ها استفاده شده‌است.[6] در این مطالعات، ارتباطی مابین این پروتئین و تشکیل آمیلوئید در بیماری آلزایمر یافت شده‌است.[7]

فنوتیپ موش‌هایی که ژن *Myd88* در آنها تخریب شده است.
مشخصه	فنوتیپ
قابیلیت حیات هوموزیگوت‌ها	نرمال
باروری	نرمال
وزن بدن	نرمال
آزمون جعبهٔ باز (استرس)	نرمال
ارزیابی مغزی-عصبی	نرمال
قدرت چنگ‌زنی	نرمال
آزمون صفحهٔ داغ	نرمال
دیس‌مورفولوژی	نرمال
کالری‌متری غیرمستقیم	نرمال
تست تحمل گلوکز	نرمال
پاسخ شنوایی ساقهٔ مغز	نرمال
سنجش تراکم استخوان	نرمال
پرتونگاری	نرمال
دمای بدن	نرمال
مورفولوژی چشم‌ها	نرمال
شیمی بالینی	نرمال
خون‌شناسی	نرمال
لنفوسیت‌های محیطی خون	نرمال
تست میکرونوکلئوس	نرمال
وزن قلب	نرمال
عفونت سالمونلا	غیرطبیعی[8]
تمامی آزمون‌ها و آنالیزها از:[9][10]

در انسان، جهش در جایگاه ۲۶۵ این ژن، سبب بروز لنفوم غیر هاچکین از نوع «لنفوم سلول B منتشر»[11] و «ماکروگلُبولینمی والندشتروم»[12] می‌گردد.

همچنین پلی‌مورفیسم در این ژن با بروز برخی بیماری‌های عفونی[13] و کولیت اولسروز[14] مرتبط است.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000032508 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)".
Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE (Jan 1997). "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family". FEBS Letters. 402 (1): 81–4. doi:10.1016/S0014-5793(96)01506-2. PMID 9013863.
Lord KA, Hoffman-Liebermann B, Liebermann DA (Jul 1990). "Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6". Oncogene. 5 (7): 1095–7. PMID 2374694.
Lim JE, Kou J, Song M, Pattanayak A, Jin J, Lalonde R, Fukuchi K (Sep 2011). "MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease". The American Journal of Pathology. 179 (3): 1095–103. doi:10.1016/j.ajpath.2011.05.045. PMC 3157279. PMID 21763676.
"Salmonella infection data for Myd88". Wellcome Trust Sanger Institute.
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
Mouse Resources Portal, Wellcome Trust Sanger Institute.
Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM (2011). "Oncogenically active MYD88 mutations in human lymphoma". Nature. 470 (7332): 115–9. doi:10.1038/nature09671. PMC 5024568. PMID 21179087.
Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR (2012). "MYD88 L265P somatic mutation in Waldenström's macroglobulinemia". N. Engl. J. Med. 367 (9): 826–33. doi:10.1056/NEJMoa1200710. PMID 22931316.
Netea MG, Wijmenga C, O'Neill LA (Jun 2012). "Genetic variation in Toll-like receptors and disease susceptibility". Nature Immunology. 13 (6): 535–42. doi:10.1038/ni.2284. PMID 22610250.
Matsunaga K, Tahara T, Shiroeda H, Otsuka T, Nakamura M, Shimasaki T, Toshikuni N, Kawada N, Shibata T, Arisawa T (Jan 2014). "The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis". Molecular Medicine Reports. 9 (1): 28–32. doi:10.3892/mmr.2013.1769. PMID 24189845.

مشارکت‌کنندگان ویکی‌پدیا. «MYD88». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۱ ژانویه ۲۰۱۸.

بیشتر بخوانید

Hardiman G, Rock FL, Balasubramanian S, Kastelein RA, Bazan JF (Dec 1996). "Molecular characterization and modular analysis of human MyD88". Oncogene. 13 (11): 2467–75. PMID 8957090.
Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE (Jan 1997). "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family". FEBS Letters. 402 (1): 81–4. doi:10.1016/S0014-5793(96)01506-2. PMID 9013863.
Hardiman G, Jenkins NA, Copeland NG, Gilbert DJ, Garcia DK, Naylor SL, Kastelein RA, Bazan JF (Oct 1997). "Genetic structure and chromosomal mapping of MyD88". Genomics. 45 (2): 332–9. doi:10.1006/geno.1997.4940. PMID 9344657.
Muzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458.
Jaunin F, Burns K, Tschopp J, Martin TE, Fakan S (Aug 1998). "Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells". Experimental Cell Research. 243 (1): 67–75. doi:10.1006/excr.1998.4131. PMID 9716450.
Lan X, Han X, Li Q, Li Q, Gao Y, Cheng T, Wan J, Zhu W, Wang J (March 2017). "Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia". Brain, behavior, and immunity. 61: 326–339. doi:10.1016/j.bbi.2016.12.012. PMID 28007523.
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (Jun 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
Aliprantis AO, Yang RB, Weiss DS, Godowski P, Zychlinsky A (Jul 2000). "The apoptotic signaling pathway activated by Toll-like receptor-2". The EMBO Journal. 19 (13): 3325–36. doi:10.1093/emboj/19.13.3325. PMC 313930. PMID 10880445.
Rhee SH, Hwang D (Nov 2000). "Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase". The Journal of Biological Chemistry. 275 (44): 34035–40. doi:10.1074/jbc.M007386200. PMID 10952994.
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.
Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, Imler JL (Jan 2002). "Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections". Nature Immunology. 3 (1): 91–7. doi:10.1038/ni747. PMID 11743586.
Bannerman DD, Tupper JC, Kelly JD, Winn RK, Harlan JM (Feb 2002). "The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta". The Journal of Clinical Investigation. 109 (3): 419–25. doi:10.1172/JCI14774. PMC 150862. PMID 11828002.
Tamai R, Sakuta T, Matsushita K, Torii M, Takeuchi O, Akira S, Akashi S, Espevik T, Sugawara S, Takada H (Mar 2002). "Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression". Infection and Immunity. 70 (3): 1272–8. doi:10.1128/IAI.70.3.1272-1278.2002. PMC 127773. PMID 11854210.
Radons J, Gabler S, Wesche H, Korherr C, Hofmeister R, Falk W (May 2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling". The Journal of Biological Chemistry. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
Janssens S, Burns K, Tschopp J, Beyaert R (Mar 2002). "Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88". Current Biology. 12 (6): 467–71. doi:10.1016/S0960-9822(02)00712-1. PMID 11909531.
Li S, Strelow A, Fontana EJ, Wesche H (Apr 2002). "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5567–72. doi:10.1073/pnas.082100399. PMC 122810. PMID 11960013.
Medvedev AE, Lentschat A, Wahl LM, Golenbock DT, Vogel SN (Nov 2002). "Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells". Journal of Immunology. 169 (9): 5209–16. doi:10.4049/jimmunol.169.9.5209. PMID 12391239.
Raschi E, Testoni C, Bosisio D, Borghi MO, Koike T, Mantovani A, Meroni PL (May 2003). "Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies". Blood. 101 (9): 3495–500. doi:10.1182/blood-2002-08-2349. PMID 12531807.
Doyle SE, O'Connell R, Vaidya SA, Chow EK, Yee K, Cheng G (Apr 2003). "Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". Journal of Immunology. 170 (7): 3565–71. doi:10.4049/jimmunol.170.7.3565. PMID 12646618.

پیوند به بیرون

MyD88 Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000032508 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)".

[pmid9013863-5] Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE (Jan 1997). "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family". FEBS Letters. 402 (1): 81–4. doi:10.1016/S0014-5793(96)01506-2. PMID 9013863.

[pmid2374694-6] Lord KA, Hoffman-Liebermann B, Liebermann DA (Jul 1990). "Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6". Oncogene. 5 (7): 1095–7. PMID 2374694.

[pmid21763676-7] Lim JE, Kou J, Song M, Pattanayak A, Jin J, Lalonde R, Fukuchi K (Sep 2011). "MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease". The American Journal of Pathology. 179 (3): 1095–103. doi:10.1016/j.ajpath.2011.05.045. PMC 3157279. PMID 21763676.

[''Salmonella''_infection-8] "Salmonella infection data for Myd88". Wellcome Trust Sanger Institute.

[mgp_reference-9] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.

[10] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[pmid21179087-11] Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM (2011). "Oncogenically active MYD88 mutations in human lymphoma". Nature. 470 (7332): 115–9. doi:10.1038/nature09671. PMC 5024568. PMID 21179087.

[pmid22931316-12] Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR (2012). "MYD88 L265P somatic mutation in Waldenström's macroglobulinemia". N. Engl. J. Med. 367 (9): 826–33. doi:10.1056/NEJMoa1200710. PMID 22931316.

[pmid_=_22610250-13] Netea MG, Wijmenga C, O'Neill LA (Jun 2012). "Genetic variation in Toll-like receptors and disease susceptibility". Nature Immunology. 13 (6): 535–42. doi:10.1038/ni.2284. PMID 22610250.

[pmid_=_24189845-14] Matsunaga K, Tahara T, Shiroeda H, Otsuka T, Nakamura M, Shimasaki T, Toshikuni N, Kawada N, Shibata T, Arisawa T (Jan 2014). "The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis". Molecular Medicine Reports. 9 (1): 28–32. doi:10.3892/mmr.2013.1769. PMID 24189845.