MAP4K2

MAP4K2
معین‌کننده‌ها
نام‌های دیگر	MAP4K2, BL44, GCK, RAB8IP, mitogen-activated protein kinase kinase kinase kinase 2
شناسه‌های بیرونی	OMIM: 603166 MGI: 1346883 HomoloGene: 3370 GeneCards: MAP4K2
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • mitogen-activated protein kinase kinase kinase binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948 پیوند پروتئینی; • ATP binding; • MAP kinase kinase kinase kinase activity;
ترکیبات سلولی	• دستگاه گلژی; • membrane; • Golgi membrane; • پوسته یاخته; • basolateral plasma membrane; • سیتوپلاسم;
فرایند زیستی	• GO:0007243 intracellular signal transduction; • vesicle targeting; • activation of JUN kinase activity; • فسفرگیری; • immune system process; • positive regulation of JNK cascade; • protein phosphorylation; • JNK cascade; • immune response; • دستگاه ایمنی ذاتی; • activation of MAPKKK activity; • regulation of mitotic cell cycle; • regulation of apoptotic process; • ورارسانی پیام; • stress-activated protein kinase signaling cascade; • activation of protein kinase activity;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5871
	26412
	ENSG00000168067
	ENSMUSG00000024948
	Q12851
	Q61161
	NM_001307990، NM_004579، XM_011545203، XM_017018093، XM_017018094، XM_017018095، XM_017018096، XR_001747932 XM_011545204، NM_001307990، NM_004579، XM_011545203، XM_017018093، XM_017018094، XM_017018095، XM_017018096، XR_001747932
	NM_009006، NR_117093، XM_006531755، XM_006531756، XM_006531757، XM_006531758، XM_006531760، XM_017318211، XM_017318212، XR_001782591 NM_001291787، NM_009006، NR_117093، XM_006531755، XM_006531756، XM_006531757، XM_006531758، XM_006531760، XM_017318211، XM_017318212، XR_001782591
	NP_004570، XP_011543506، XP_016873582، XP_016873584، XP_024304397، XP_024304398، XP_024304399، XP_024304401، XP_024304402 NP_001294919، NP_004570، XP_011543506، XP_016873582، XP_016873584، XP_024304397، XP_024304398، XP_024304399، XP_024304401، XP_024304402
	NP_033032، XP_006531818، XP_006531819، XP_006531820، XP_006531823، XP_017173700، XP_017173701، XP_036017493 NP_001278716، NP_033032، XP_006531818، XP_006531819، XP_006531820، XP_006531823، XP_017173700، XP_017173701، XP_036017493
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین کیناز کیناز کیناز کیناز ۲ فعال‌شونده توسط میتوژن (انگلیسی: Mitogen-activated protein kinase kinase kinase kinase 2‎) یک آنزیم است که در انسان توسط ژن «MAP3K10» کُدگذاری می‌شود.[3][4]

این پروتئین با RAB8A[5] و TRAF2[6] تعامل پروتئین-پروتئین دارد.

منابع

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Katz P, Whalen G, Kehrl JH (Jun 1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center". The Journal of Biological Chemistry. 269 (24): 16802–9. PMID 7515885.
"Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2".
Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. PMC 39423. PMID 8643544.
Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". The Journal of Biological Chemistry. 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. PMID 9712898.

مشارکت‌کنندگان ویکی‌پدیا. «MAP4K2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۸ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر

Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa P (Apr 1992). "Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus". Nature. 356 (6371): 721–2. doi:10.1038/356721a0. PMID 1570017.
Matsutani A, Janssen R, Donis-Keller H, Permutt MA (Feb 1992). "A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p". Genomics. 12 (2): 319–25. doi:10.1016/0888-7543(92)90380-B. PMID 1740341.
Pombo CM, Kehrl JH, Sánchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM (Oct 1995). "Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase". Nature. 377 (6551): 750–4. doi:10.1038/377750a0. PMID 7477268.
Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. PMC 39423. PMID 8643544.
Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (Jul 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Research. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". The Journal of Biological Chemistry. 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. PMID 9712898.
Chadee DN, Yuasa T, Kyriakis JM (Feb 2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2". Molecular and Cellular Biology. 22 (3): 737–49. doi:10.1128/MCB.22.3.737-749.2002. PMC 133545. PMID 11784851.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (Mar 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7515885-3] Katz P, Whalen G, Kehrl JH (Jun 1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center". The Journal of Biological Chemistry. 269 (24): 16802–9. PMID 7515885.

[entrez-4] "Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2".

[pmid8643544-5] Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. PMC 39423. PMID 8643544.

[pmid9712898-6] Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". The Journal of Biological Chemistry. 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. PMID 9712898.