LY75

LY75
معین‌کننده‌ها
نام‌های دیگر	LY75, CD205, CLEC13B, DEC-205, GP200-MR6, LY-75, lymphocyte antigen 75
شناسه‌های بیرونی	OMIM: 604524 MGI: 106662 HomoloGene: 31085 GeneCards: LY75
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[1]
End	60,383,303 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948 پیوند پروتئینی; • carbohydrate binding; • transmembrane signaling receptor activity; • signaling receptor activity;
ترکیبات سلولی	• integral component of membrane; • integral component of plasma membrane; • extracellular exosome; • membrane;
فرایند زیستی	• inflammatory response; • اندوسیتوز; • immune response; • ورارسانی پیام;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4065
	17076
	ENSG00000054219
	ENSMUSG00000026980
	O60449
	Q60767
	NM_002349
	NM_013825
	NP_001185689 NP_001185688، NP_001185689
	NP_038853
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

آنتی‌ژن لنفوسیتی ۷۵ (انگلیسی: Lymphocyte antigen 75‎) یک پروتئین است که در انسان توسط ژن «LY75» کُدگذاری می‌شود.[4][5]

این پروتئین با نام‌های CD205 و DEC-205 هم شناخته می‌شود.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000026980 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells". Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150.
"Entrez Gene: LY75 lymphocyte antigen 75".

مشارکت‌کنندگان ویکی‌پدیا. «LY75». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۷ دسامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

Tungekar MF, Gatter KC, Ritter MA (1996). "Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124)". Br. J. Cancer. 73 (4): 429–32. doi:10.1038/bjc.1996.77. PMC 2074450. PMID 8595155.
al-Tubuly AA, Luqmani YA, Shousha S, et al. (1996). "Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast". Br. J. Cancer. 74 (7): 1005–11. doi:10.1038/bjc.1996.481. PMC 2077117. PMID 8855966.
McKay PF, Imami N, Johns M, et al. (1999). "The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family". Eur. J. Immunol. 28 (12): 4071–83. doi:10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O. PMID 9862343.
Palmer DB, Crompton T, Marandi MB, et al. (1999). "Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development". Immunology. 96 (2): 236–45. doi:10.1046/j.1365-2567.1999.00691.x. PMC 2326733. PMID 10233701.
Guo M, Gong S, Maric S, et al. (2000). "A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells". Hum. Immunol. 61 (8): 729–38. doi:10.1016/S0198-8859(00)00144-0. PMID 10980384.
Kato M, Neil TK, Fearnley DB, et al. (2000). "Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells". Int. Immunol. 12 (11): 1511–9. doi:10.1093/intimm/12.11.1511. PMID 11058570.
Kato M, Khan S, Gonzalez N, et al. (2003). "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.
Bozzacco L, Trumpfheller C, Siegal FP, et al. (2007). "DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1289–94. doi:10.1073/pnas.0610383104. PMC 1783096. PMID 17229838.
Nonaka D, Henley JD, Chiriboga L, Yee H (2007). "Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms". Am. J. Surg. Pathol. 31 (7): 1038–44. doi:10.1097/PAS.0b013e31802b4917. PMID 17592270.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000026980 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9553150-4] Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells". Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150.

[entrez-5] "Entrez Gene: LY75 lymphocyte antigen 75".