KLRG1

KLRG1
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FF7
معین‌کننده‌ها
نام‌های دیگر	KLRG1, 2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE, killer cell lectin like receptor G1
شناسه‌های بیرونی	OMIM: 604874 MGI: 1355294 HomoloGene: 4244 GeneCards: KLRG1
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[1]
End	122,282,882 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948 پیوند پروتئینی; • carbohydrate binding; • signaling receptor activity;
ترکیبات سلولی	• پوسته یاخته; • membrane; • integral component of membrane; • intracellular membrane-bounded organelle;
فرایند زیستی	• دستگاه ایمنی ذاتی; • inflammatory response; • immune system process; • cellular defense response; • cell surface receptor signaling pathway;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10219
	50928
	ENSG00000139187
	ENSMUSG00000030114
	Q96E93
	O88713
	NM_001329101، NM_001329102، NM_001329103، NM_005810، NR_137426، NR_137427، NR_137428، XM_017018682، XM_017018683، XM_017018684، XM_017018685 NM_001329099، NM_001329101، NM_001329102، NM_001329103، NM_005810، NR_137426، NR_137427، NR_137428، XM_017018682، XM_017018683، XM_017018684، XM_017018685
	NM_016970
	NP_001316030، NP_001316031، NP_001316032، NP_005801، XP_016874171، XP_016874172، XP_016874173، XP_016874174 NP_001316028، NP_001316030، NP_001316031، NP_001316032، NP_005801، XP_016874171، XP_016874172، XP_016874173، XP_016874174
	NP_058666
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

گیرندهٔ شبه لکتینی سلول کُشنده، خانوادهٔ G عضو ۱ (انگلیسی: Killer cell lectin-like receptor subfamily G member 1‎) یک پروتئین است که در انسان توسط ژن «KLRG1» کُدگذاری می‌شود.[4][5][6][7][8]

سلول‌های کشنده طبیعی، لنفوسیت‌هایی هستند که در تجزیه و کشتار برخی انواع سلول‌های توموری یا آلوده‌شده به ویروس نقش دارند و نیازی به فعال‌شدگی قبلی هم ندارند. این سلول‌ها در تنظیم ایمنی سلولی و ایمنی هومورال هم دخالت دارند.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000030114 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hanke T, Corral L, Vance RE, Raulet DH (December 1998). "2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells". European Journal of Immunology. 28 (12): 4409–17. doi:10.1002/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO;2-3. PMID 9862378.
Butcher S, Arney KL, Cook GP (November 1998). "MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells". European Journal of Immunology. 28 (11): 3755–62. doi:10.1002/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3. PMID 9842918.
Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N (February 2006). "Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity". The Journal of Experimental Medicine. 203 (2): 289–95. doi:10.1084/jem.20051986. PMC 2118217. PMID 16461340.
Thimme R, Appay V, Koschella M, Panther E, Roth E, Hislop AD, Rickinson AB, Rowland-Jones SL, Blum HE, Pircher H (September 2005). "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation". Journal of Virology. 79 (18): 12112–6. doi:10.1128/JVI.79.18.12112-12116.2005. PMC 1212638. PMID 16140789.
"Entrez Gene: KLRG1 killer cell lectin-like receptor subfamily G, member 1".

مشارکت‌کنندگان ویکی‌پدیا. «KLRG1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۹ دسامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

Ortega E, Schneider H, Pecht I (April 1991). "Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen". International Immunology. 3 (4): 333–42. doi:10.1093/intimm/3.4.333. PMID 1831652.
Lamers MB, Lamont AG, Williams DH (August 1998). "Human MAFA has alternatively spliced variants". Biochimica et Biophysica Acta. 1399 (2–3): 209–12. doi:10.1016/s0167-4781(98)00107-9. PMID 9765598.
Voehringer D, Koschella M, Pircher H (November 2002). "Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)". Blood. 100 (10): 3698–702. doi:10.1182/blood-2002-02-0657. PMID 12393723.
Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R (March 2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proceedings of the National Academy of Sciences of the United States of America. 101 (9): 2930–3. doi:10.1073/pnas.0306233101. PMC 365722. PMID 14973194.
Marcolino I, Przybylski GK, Koschella M, Schmidt CA, Voehringer D, Schlesier M, Pircher H (October 2004). "Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history". European Journal of Immunology. 34 (10): 2672–80. doi:10.1002/eji.200425282. PMID 15368283.
Ibegbu CC, Xu YX, Harris W, Maggio D, Miller JD, Kourtis AP (May 2005). "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57". Journal of Immunology. 174 (10): 6088–94. doi:10.4049/jimmunol.174.10.6088. PMID 15879103.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsäcker F, Blum HE, Pircher H, Thimme R (January 2007). "Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver". Journal of Virology. 81 (2): 945–53. doi:10.1128/JVI.01354-06. PMC 1797464. PMID 17079288.
Schwartzkopff S, Gründemann C, Schweier O, Rosshart S, Karjalainen KE, Becker KF, Pircher H (July 2007). "Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans". Journal of Immunology. 179 (2): 1022–9. doi:10.4049/jimmunol.179.2.1022. PMID 17617594.

پیوند به بیرون

مکان ژن انسانی KLRG1 در مرورگر ژنومی UCSC.
جزئیات ژن انسانی KLRG1 در مرورگر ژنومی UCSC.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q96E93 (گیرندهٔ شبه لکتینی سلول کُشنده، خانوادهٔ G عضو ۱) در PDBe-KB.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000030114 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hanke_1999-4] Hanke T, Corral L, Vance RE, Raulet DH (December 1998). "2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells". European Journal of Immunology. 28 (12): 4409–17. doi:10.1002/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO;2-3. PMID 9862378.

[Butcher_1998-5] Butcher S, Arney KL, Cook GP (November 1998). "MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells". European Journal of Immunology. 28 (11): 3755–62. doi:10.1002/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3. PMID 9842918.

[Ito_2006-6] Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N (February 2006). "Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity". The Journal of Experimental Medicine. 203 (2): 289–95. doi:10.1084/jem.20051986. PMC 2118217. PMID 16461340.

[Thimme_2005-7] Thimme R, Appay V, Koschella M, Panther E, Roth E, Hislop AD, Rickinson AB, Rowland-Jones SL, Blum HE, Pircher H (September 2005). "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation". Journal of Virology. 79 (18): 12112–6. doi:10.1128/JVI.79.18.12112-12116.2005. PMC 1212638. PMID 16140789.

[entrez-8] "Entrez Gene: KLRG1 killer cell lectin-like receptor subfamily G, member 1".