گیرنده ۳ بی سروتونین

HTR3B
معین‌کننده‌ها
نام‌های دیگر	HTR3B, 5-HT3B, 5-hydroxytryptamine receptor 3B
شناسه‌های بیرونی	OMIM: 604654 MGI: 1861899 HomoloGene: 38131 GeneCards: HTR3B
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[1]
End	48,964,990 bp[1]
هستی‌شناسی ژن
عملکرد ملکولی	• extracellular ligand-gated ion channel activity; • ligand-gated ion channel activity; • serotonin-gated cation-selective channel activity; • ion channel activity; • transmembrane signaling receptor activity;
ترکیبات سلولی	• integral component of membrane; • membrane; • cell surface; • پوسته یاخته; • postsynaptic membrane; • integral component of plasma membrane; • serotonin-activated cation-selective channel complex; • neuron projection; • سیناپس;
فرایند زیستی	• ion transport; • ورارسانی پیام; • ion transmembrane transport; • serotonin receptor signaling pathway; • chemical synaptic transmission; • regulation of membrane potential; • nervous system process;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	9177
	57014
	ENSG00000149305
	ENSMUSG00000008590
	O95264
	Q9JHJ5
	XM_017018552، XR_001748034، XM_024448767، NM_001363563 NM_006028، XM_017018552، XR_001748034، XM_024448767، NM_001363563
	NM_020274
	XP_016874041، XP_024304535، NP_001350492 NP_006019، XP_016874041، XP_024304535، NP_001350492
	NP_064670
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

گیرنده ۳ بی سروتونین (انگلیسی: 5-hydroxytryptamine (serotonin) receptor 3B‎) یک پروتئین است که در انسان توسط ژن «HTR3B» کُدگذاری می‌شود.

پروتئین کُدشده توسط ژن «HTR3B» یکی از زیرواحدهای گیرنده ۳ سروتونین است.[4][5]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000008590 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–363. doi:10.1038/16941. PMID 9950429. S2CID 4401851.
Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–30810. doi:10.1074/jbc.274.43.30799. PMID 10521471.

مشارکت‌کنندگان ویکی‌پدیا. «HTR3B». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۸ اکتبر ۲۰۲۰.

برای مطالعهٔ بیشتر

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Meineke C, Tzvetkov MV, Bokelmann K, et al. (2008). "Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene". Pharmacogenet. Genomics. 18 (3): 219–230. doi:10.1097/FPC.0b013e3282f51092. PMID 18300944. S2CID 44722598.
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Krzywkowski K, Davies PA, Feinberg-Zadek PL, et al. (2008). "High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor". Proc. Natl. Acad. Sci. U.S.A. 105 (2): 722–727. doi:10.1073/pnas.0708454105. PMC 2206603. PMID 18184810.
Ji X, Takahashi N, Branko A, et al. (2008). "An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population". Nagoya Journal of Medical Science. 70 (1–2): 11–17. PMID 18807291.
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Yosifova A, Mushiroda T, Stoianov D, et al. (2009). "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population". Journal of Affective Disorders. 117 (1–2): 87–97. doi:10.1016/j.jad.2008.12.021. PMID 19328558.
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پیوند به بیرون

HTR3B protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000008590 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9950429-4] Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–363. doi:10.1038/16941. PMID 9950429. S2CID 4401851.

[pmid10521471-5] Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–30810. doi:10.1074/jbc.274.43.30799. PMID 10521471.