پروتئین بازی اصلی

Proteoglycan 2, pro eosinophil major basic protein
معین‌کننده‌ها
نام‌های دیگر	eosinophil major basic proteineosinophil granule major basic proteinbone marrow proteoglycanproteoglycan 2 preproproteinPRG2Proteoglycan 2natural killer cell activatorproteoglycan 2bone marrow (natural killer cell activatoreosinophil granule major basic protein)
شناسه‌های بیرونی	GeneCards:
الگوی گسترش RNA
	More reference expression data
هم‌ساخت‌شناسی
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ویکی‌داده
مشاهده/ویرایش Human

پروتئین بازی اصلی ائوزینوفیل (انگلیسی: Eosinophil major basic protein‎) یک پروتئین است که در انسان توسط ژن «PRG2» کُدگذاری می‌شود.[1] این پروتئین، مادهٔ اصلی درون‌مایهٔ کریستالی گرانول‌های ائوزینوفیل است. میزان زیادی از پیش‌ساز این مولکول در جفت و سرم خون زنان باردار، به‌ویژه در ترکیب با پروتئین‌هایی چون PAPPA، آنژیوتانسینوژن و C3dg یافت می‌شود.

جستارهای وابسته

آریل‌سولفاتاز

منابع

"Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)".

مشارکت‌کنندگان ویکی‌پدیا. «Major basic protein». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۸ نوامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

Vanhaesebroeck B, Alessi DR (2000). "The PI3K-PDK1 connection: more than just a road to PKB". Biochem. J. 346 (3): 561–76. doi:10.1042/0264-6021:3460561. PMC 1220886. PMID 10698680.
Yoshimatsu K, Ohya Y, Shikata Y, et al. (1992). "Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins". Mol. Immunol. 29 (4): 537–546. doi:10.1016/0161-5890(92)90012-M. PMID 1565101.
Barker RL, Loegering DA, Arakawa KC, et al. (1990). "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein". Gene. 86 (2): 285–289. doi:10.1016/0378-1119(90)90292-Y. PMID 2323577.
Gabay JE, Scott RW, Campanelli D, et al. (1989). "Antibiotic proteins of human polymorphonuclear leukocytes". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5610–5614. Bibcode:1989PNAS...86.5610G. doi:10.1073/pnas.86.14.5610. PMC 297672. PMID 2501794.
Wasmoen TL, McKean DJ, Benirschke K, et al. (1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6): 2051–2063. doi:10.1084/jem.170.6.2051. PMC 2189540. PMID 2584934.
Barker RL, Gleich GJ, Pease LR (1988). "Acidic precursor revealed in human eosinophil granule major basic protein cDNA". J. Exp. Med. 168 (4): 1493–1498. doi:10.1084/jem.168.4.1493. PMC 2189086. PMID 3171483.
McGrogan M, Simonsen C, Scott R, et al. (1989). "Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein". J. Exp. Med. 168 (6): 2295–2308. doi:10.1084/jem.168.6.2295. PMC 2189145. PMID 3199069.
Wasmoen TL, Bell MP, Loegering DA, et al. (1988). "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein". J. Biol. Chem. 263 (25): 12559–63. PMID 3410852.
Weller PF, Ackerman SJ, Smith JA (1988). "Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. Leukoc. Biol. 43 (1): 1–4. doi:10.1002/jlb.43.1.1. PMID 3422083.
Kristensen T, Oxvig C, Sand O, et al. (1994). "Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA". Biochemistry. 33 (6): 1592–1598. doi:10.1021/bi00172a040. PMID 7508748.
Oxvig C, Haaning J, Højrup P, Sottrup-Jensen L (1994). "Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum". Biochem. Mol. Biol. Int. 33 (2): 329–36. PMID 7524900.
Bonno M, Oxvig C, Kephart GM, et al. (1994). "Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta". Lab. Invest. 71 (4): 560–6. PMID 7526035.
Li MS, Sun L, Satoh T, et al. (1995). "Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters". Biochem. J. 305 (3): 921–7. doi:10.1042/bj3050921. PMC 1136346. PMID 7531438.
Oxvig C, Haaning J, Kristensen L, et al. (1995). "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma". J. Biol. Chem. 270 (23): 13645–13651. doi:10.1074/jbc.270.23.13645. PMID 7539791.
Oxvig C, Sand O, Kristensen T, et al. (1993). "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein". J. Biol. Chem. 268 (17): 12243–6. PMID 7685339.
Levi-Schaffer F, Lacy P, Severs NJ, et al. (1995). "Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils". Blood. 85 (9): 2579–86. PMID 7727786.
Oxvig C, Gleich GJ, Sottrup-Jensen L (1994). "Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein" (PDF). FEBS Lett. 341 (2–3): 213–217. doi:10.1016/0014-5793(94)80459-1. PMID 8137941.
Shikata Y, Hayashi Y, Yoshimatsu K, et al. (1993). "Pro-major basic protein has three types of sugar chains at the pro-portion". Biochim. Biophys. Acta. 1163 (3): 243–9. doi:10.1016/0167-4838(93)90158-N. PMID 8507662.
Nittoh T, Watanabe M, Okayama H, et al. (1996). "Cloning of cDNA for rat eosinophil major basic protein". Biochim. Biophys. Acta. 1264 (3): 261–4. doi:10.1016/0167-4781(95)00183-2. PMID 8547309.
Delcommenne M, Tan C, Gray V, et al. (1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11211–11216. Bibcode:1998PNAS...9511211D. doi:10.1073/pnas.95.19.11211. PMC 21621. PMID 9736715.

پیوند به بیرون

Eosinophil Major Basic Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[entrez-1] "Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)".