نئورگولین ۳

NRG3
معین‌کننده‌ها
نام‌های دیگر	NRG3, HRG3, pro-neuregulin 3
شناسه‌های بیرونی	OMIM: 605533 MGI: 1097165 HomoloGene: 32051 GeneCards: NRG3
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[1]
End	39,473,088 bp[1]
هستی‌شناسی ژن
عملکرد ملکولی	• receptor tyrosine kinase binding; • growth factor activity; • transmembrane receptor protein tyrosine kinase activator activity; • chemorepellent activity; • signaling receptor binding;
ترکیبات سلولی	• integral component of membrane; • extracellular region; • پوسته یاخته; • integral component of plasma membrane; • intracellular anatomical structure; • membrane; • extracellular space; • glutamatergic synapse;
فرایند زیستی	• pattern specification process; • mammary placode formation; • chemorepulsion involved in interneuron migration from the subpallium to the cortex; • negative regulation of neuron migration; • regulation of cell growth; • mammary gland development; • activation of transmembrane receptor protein tyrosine kinase activity; • GO:0007243 intracellular signal transduction; • animal organ development; • regulation of signaling receptor activity; • جنین‌شناسی دستگاه عصبی مرکزی; • modulation of chemical synaptic transmission;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10718
	18183
	ENSG00000185737
	ENSMUSG00000041014
	P56975
	O35181
	NM_001165972، NM_001165973، XM_011539172، XM_011539173، XM_011539175، XM_011539178، XM_017015573، XM_017015574، XM_017015575، XM_017015576، XM_017015577، XM_017015578، XM_017015579، XM_017015580، XM_017015582، XM_017015583، XM_017015584، XR_001747009، XM_024447781، NM_001370081، NM_001370082، NM_001370083، NM_001370084، NR_163251، NR_163252، NR_163253 NM_001010848، NM_001165972، NM_001165973، XM_011539172، XM_011539173، XM_011539175، XM_011539178، XM_017015573، XM_017015574، XM_017015575، XM_017015576، XM_017015577، XM_017015578، XM_017015579، XM_017015580، XM_017015582، XM_017015583، XM_017015584، XR_001747009، XM_024447781، NM_001370081، NM_001370082، NM_001370083، NM_001370084، NR_163251، NR_163252، NR_163253
	NM_001190188، NM_008734، XM_006518685، XM_006518686، XM_006518687، XM_011244987، XM_017315910، XM_017315911، XM_030247684 NM_001190187، NM_001190188، NM_008734، XM_006518685، XM_006518686، XM_006518687، XM_011244987، XM_017315910، XM_017315911، XM_030247684
	NP_001159444، NP_001159445، XP_011537474، XP_011537475، XP_011537477، XP_011537480، XP_016871062، XP_016871063، XP_016871064، XP_016871065، XP_016871066، XP_016871067، XP_016871068، XP_016871069، XP_016871071، XP_016871072، XP_016871073، XP_024303549، NP_001357010، NP_001357011، NP_001357012، NP_001357013 NP_001010848، NP_001159444، NP_001159445، XP_011537474، XP_011537475، XP_011537477، XP_011537480، XP_016871062، XP_016871063، XP_016871064، XP_016871065، XP_016871066، XP_016871067، XP_016871068، XP_016871069، XP_016871071، XP_016871072، XP_016871073، XP_024303549، NP_001357010، NP_001357011، NP_001357012، NP_001357013
	NP_001177117، NP_032760، XP_006518748، XP_006518749، XP_006518750، XP_011243289، XP_017171399، XP_017171400، XP_030103544، XP_036014398، XP_036014399 NP_001177116، NP_001177117، NP_032760، XP_006518748، XP_006518749، XP_006518750، XP_011243289، XP_017171399، XP_017171400، XP_030103544، XP_036014398، XP_036014399
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

نئورگولین ۳ (انگلیسی: Neuregulin 3‎) نام پروتئینی است که در انسان توسط ژن «NRG3» کُد می‌شود.[4][5]

این پروتئین به دومِـینِ خارج‌سلولیِ تیروزین کیناز گیرنده‌ای ERBB4 متصل شده و موجب فسفریلاسیون آن می‌شود.[5] نئورگولین ۳ به گیرنده‌های ERBB2 و ERBB3 اتصال نمی‌یابد.

برخی از واریان‌های ژنی NRG3 را، در استعدادِ ژنتیکی افراد به ابتلا به بیماری اسکیزوفرنی دخیل دانسته‌اند.[6] همچنین این پروتئین را با بروز بیماری هیرشپرونگ مرتبط دانسته‌اند.[7]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000041014 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: NRG3 neuregulin 3".
Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (September 1997). "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. doi:10.1073/pnas.94.18.9562. PMC 23218. PMID 9275162.
Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D (January 2009). "Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia". Am. J. Hum. Genet. 84 (1): 21–34. doi:10.1016/j.ajhg.2008.12.005. PMC 2668048. PMID 19118813. Lay summary – The Johns Hopkins News-Letter.
Yang J, Duan S, Zhong R, Yin J, Pu J, Ke J, Lu X, Zou L, Zhang H, Zhu Z, Wang D, Xiao H, Guo A, Xia J, Miao X, Tang S, Wang G (January 2013). "Exome Sequencing Identified NRG3 as a Novel Susceptible Gene of Hirschsprung's Disease in a Chinese Population". Mol. Neurobiol. 47: 957–966. doi:10.1007/s12035-012-8392-4. PMID 23315268.

مشارکت‌کنندگان ویکی‌پدیا. «Neuregulin 3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۶ نوامبر ۲۰۱۷.

بیشتر بخوانید

Benzel I, Bansal A, Browning BL, et al. (2007). "Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia". Behavioral and Brain Functions. 3 (1): 31. doi:10.1186/1744-9081-3-31. PMC 1934910. PMID 17598910.
Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology. 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380.
Shrestha S, Irvin MR, Taylor KD, et al. (2010). "A genome-wide association study of carotid atherosclerosis in HIV-infected men". AIDS. 24 (4): 583–92. doi:10.1097/QAD.0b013e3283353c9e. PMC 3072760. PMID 20009918.
Uhl GR, Liu QR, Drgon T, et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results". Arch. Gen. Psychiatry. 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gizatullin RZ, Muravenko OV, Al-Amin AN, et al. (2000). "Human NRG3 gene Map position 10q22-q23". Chromosome Res. 8 (6): 560. doi:10.1023/A:1009232025144. PMID 11032326.
Panchal H, Wansbury O, Parry S, et al. (2007). "Neuregulin3 alters cell fate in the epidermis and mammary gland". BMC Dev. Biol. 7: 105. doi:10.1186/1471-213X-7-105. PMC 2110892. PMID 17880691.
Wang YC, Chen JY, Chen ML, et al. (2008). "Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population". Biol. Psychiatry. 64 (12): 1093–6. doi:10.1016/j.biopsych.2008.07.012. PMID 18708184.
Révillion F, Lhotellier V, Hornez L, et al. (2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. 19 (1): 73–80. doi:10.1093/annonc/mdm431. PMID 17962208.
Carteron C, Ferrer-Montiel A, Cabedo H (2006). "Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival". J. Cell Sci. 119 (Pt 5): 898–909. doi:10.1242/jcs.02799. PMID 16478787.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sonuga-Barke EJ, Lasky-Su J, Neale BM, et al. (2008). "Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8): 1359–68. doi:10.1002/ajmg.b.30860. PMID 18846501.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Volpi S, Heaton C, Mack K, et al. (2009). "Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia". Mol. Psychiatry. 14 (11): 1024–31. doi:10.1038/mp.2008.52. PMID 18521091.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000041014 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: NRG3 neuregulin 3".

[pmid9275162-5] Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (September 1997). "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. doi:10.1073/pnas.94.18.9562. PMC 23218. PMID 9275162.

[pmid19118813-6] Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D (January 2009). "Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia". Am. J. Hum. Genet. 84 (1): 21–34. doi:10.1016/j.ajhg.2008.12.005. PMC 2668048. PMID 19118813. Lay summary – The Johns Hopkins News-Letter.

[pmid23315268-7] Yang J, Duan S, Zhong R, Yin J, Pu J, Ke J, Lu X, Zou L, Zhang H, Zhu Z, Wang D, Xiao H, Guo A, Xia J, Miao X, Tang S, Wang G (January 2013). "Exome Sequencing Identified NRG3 as a Novel Susceptible Gene of Hirschsprung's Disease in a Chinese Population". Mol. Neurobiol. 47: 957–966. doi:10.1007/s12035-012-8392-4. PMID 23315268.