EMR1

ADGRE1
معین‌کننده‌ها
نام‌های دیگر	ADGRE1, TM7LN3, EMR1, adhesion G protein-coupled receptor E1
شناسه‌های بیرونی	OMIM: 600493 MGI: 106912 HomoloGene: 1493 GeneCards: ADGRE1
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[1]
End	57,483,527 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• calcium ion binding; • G protein-coupled receptor activity; • transmembrane signaling receptor activity; • signal transducer activity;
ترکیبات سلولی	• integral component of membrane; • پوسته یاخته; • integral component of plasma membrane; • membrane; • external side of plasma membrane; • cell periphery; • intracellular anatomical structure;
فرایند زیستی	• G protein-coupled receptor signaling pathway; • cell surface receptor signaling pathway; • cell adhesion; • adaptive immune response; • ورارسانی پیام; • immune system process; • adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2015
	13733
	ENSG00000174837
	ENSMUSG00000004730
	Q14246
	Q61549
	NM_001256252، NM_001256253، NM_001256254، NM_001256255، NM_001974 XM_011527794، NM_001256252، NM_001256253، NM_001256254، NM_001256255، NM_001974
	XM_006523602، NM_001355722، NM_001355723 NM_010130، XM_006523602، NM_001355722، NM_001355723
	NP_001243182، NP_001243183، NP_001243184، NP_001965، XP_011526096 NP_001243181، NP_001243182، NP_001243183، NP_001243184، NP_001965، XP_011526096
	XP_006523664، XP_006523665، NP_001342651، NP_001342652 NP_034260، XP_006523664، XP_006523665، NP_001342651، NP_001342652
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

شبه گیرندهٔ ۱ هورمون شبه موسینی ماژول‌دار شبه فاکتور رشد اپیدرمی (انگلیسی: EGF-like module-containing mucin-like hormone receptor-like 1‎) یا F4/80 یک پروتئین است که در انسان توسط ژن «ADGRE1» کُدگذاری می‌شود.[4][5][6][7][8]

این گیرنده یکی از اعضای خانوادهٔ بزرگ «گیرنده‌های جفت‌شونده با پروتئین جی، ویژهٔ چسبندگی» است.[9][10]

اهمیت بالینی

این گیرنده‌ها ممکن است یکی از اهداف درمانی در اختلالات ائوزینوفیلیک باشد.[11]

جستارهای وابسته

EMR

منابع

GRCm38: Ensembl release 89: ENSMUSG00000004730 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–80. PMID 9500513.
"Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".
Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. PMID 8083537.
Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165.
Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology. 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMC 4113341. PMID 24530099.

مشارکت‌کنندگان ویکی‌پدیا. «EMR1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲ ژانویه ۲۰۱۹.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000004730 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601460-4] Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.

[pmid9500513-5] McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–80. PMID 9500513.

[entrez-6] "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".

[pmid8083537-7] Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. PMID 8083537.

[8] Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-9] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.

[10] Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165.

[11] Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology. 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMC 4113341. PMID 24530099.