کارباموئیل فسفات سنتتاز II

واکنش

در بیوسنتز پیریمیدین‌ها، این آنزیم واکنش زیر را کاتالیز می‌کند: واکنش کلی:

2 ATP + L-glutamine + HCO3- + H2O \rightleftharpoons 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

(1a) L-glutamine + H2O \rightleftharpoons L-glutamate + NH3

(1b) 2 ATP + HCO3- + NH3 \rightleftharpoons 2 ADP + phosphate + carbamoyl phosphate

منابع

    [1][2][3]

    1. https://en.wikipedia.org/wiki/Carbamoyl_phosphate_synthase_II
    2. Anderson, P.M. and Meister, A. (1965). "Evidence for an activated form of carbon dioxide in the reaction catalysed by Escherichia coli carbamyl phosphate synthetase". Biochemistry 4 (12): 2803–2809
    3. Kalman, S.M. , Duffield, P.H. and Brzozowski, T. (1966). "Purification and properties of a bacterial carbamyl phosphate synthetase". J. Biol. Chem. 241 (8): 1871–1877
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