پایکارد

PYCARD
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UCP, 2KN6, 3J63, 5H8O
معین‌کننده‌ها
نام‌های دیگر	PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
شناسه‌های بیرونی	OMIM: 606838 MGI: 1931465 HomoloGene: 8307 GeneCards: PYCARD
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[1]
End	127,993,867 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • interleukin-6 receptor binding; • BMP receptor binding; • GO:0001948 پیوند پروتئینی; • identical protein binding; • enzyme binding; • cysteine-type endopeptidase activity involved in apoptotic process; • Pyrin domain binding; • cysteine-type endopeptidase activator activity involved in apoptotic process; • myosin I binding; • tropomyosin binding; • protease binding; • ion channel binding; • protein dimerization activity; • cysteine-type endopeptidase activity;
ترکیبات سلولی	• سیتوپلاسم; • NLRP3 inflammasome complex; • NLRP1 inflammasome complex; • AIM2 inflammasome complex; • هستک; • شبکه آندوپلاسمی; • میتوکندری; • IkappaB kinase complex; • هسته یاخته; • secretory granule lumen; • azurophil granule lumen; • extracellular region; • سیتوزول; • protein-containing complex; • neuronal cell body; • Golgi membrane; • دستگاه گلژی; • membrane;
فرایند زیستی	• positive regulation of cysteine-type endopeptidase activity; • regulation of apoptotic process; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of intrinsic apoptotic signaling pathway; • intrinsic apoptotic signaling pathway by p53 class mediator; • positive regulation of adaptive immune response; • defense response to Gram-negative bacterium; • immune system process; • cellular response to tumor necrosis factor; • regulation of tumor necrosis factor-mediated signaling pathway; • positive regulation of DNA-binding transcription factor activity; • tumor necrosis factor-mediated signaling pathway; • positive regulation of JNK cascade; • negative regulation of interferon-beta production; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • myeloid dendritic cell activation; • positive regulation of T cell activation; • defense response to virus; • cellular response to interleukin-1; • positive regulation of apoptotic process; • positive regulation of tumor necrosis factor production; • positive regulation of release of cytochrome c from mitochondria; • negative regulation of protein serine/threonine kinase activity; • positive regulation of extrinsic apoptotic signaling pathway; • inflammatory response; • cellular response to lipopolysaccharide; • negative regulation of NF-kappaB transcription factor activity; • ورارسانی پیام; • مرگ برنامه‌ریزی‌شده یاخته; • دستگاه ایمنی ذاتی; • neutrophil degranulation; • positive regulation of NF-kappaB transcription factor activity; • activation of innate immune response; • myeloid dendritic cell activation involved in immune response; • positive regulation of antigen processing and presentation of peptide antigen via MHC class II; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of actin filament polymerization; • regulation of protein stability; • positive regulation of interferon-gamma production; • positive regulation of interleukin-6 production; • positive regulation of activated T cell proliferation; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • macropinocytosis; • positive regulation of phagocytosis; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of T cell migration; • positive regulation of defense response to virus by host; • intrinsic apoptotic signaling pathway in response to DNA damage; • response to bacterium; • regulation of autophagy; • interleukin-1 beta production; • GO:0043087، GO:0032313، GO:0032319، GO:0032314، GO:0043088 regulation of GTPase activity; • regulation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of inflammatory response; • protein homooligomerization; • activation of cysteine-type endopeptidase activity; • negative regulation of cytokine production involved in inflammatory response; • پروتئین‌کافت; • positive regulation of interleukin-1 beta production;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	29108
	66824
	ENSG00000103490
	ENSMUSG00000030793
	Q9ULZ3
	Q9EPB4
	NM_013258، NM_145182 NM_145183، NM_013258، NM_145182
	NM_023258
	NP_660183 NP_037390، NP_660183
	NP_075747
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پایکارد (انگلیسی: PYCARD‎) که گاهی با نام «ASC» (پروتئین ذره‌ای‌شکل وابسته به آپوپتوز حاوی یک CARD) یک پروتئین است که در انسان‌ها توسط ژن «PYCARD» می‌شود.[4]

این پروتئین بیشتر در هسته یاخته، مونوسیت‌ها و ماکروفاژها دیده می‌شود اما قادر است به‌سرعت جای خود را تغییر داده و به سیتوپلاسم، فضای اطراف هسته، شبکه آندوپلاسمی و میتوکندری بیاید و مهترین پروتئین واسط در فعال‌سازی اینفلامازوم است.[5]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000030793 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PYCARD PYD and CARD domain containing". Retrieved 18 September 2010.
Dunn, JH; Fujita, M (2015). "PYCARD (PYD and CARD domain containing)". Atlas of Genetics and Cytogenetics in Oncology and Haematology (4). doi:10.4267/2042/56440. ISSN 1768-3262.

مشارکت‌کنندگان ویکی‌پدیا. «PYCARD». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۷ اکتبر ۲۰۱۷.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000030793 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: PYCARD PYD and CARD domain containing". Retrieved 18 September 2010.

[:0-5] Dunn, JH; Fujita, M (2015). "PYCARD (PYD and CARD domain containing)". Atlas of Genetics and Cytogenetics in Oncology and Haematology (4). doi:10.4267/2042/56440. ISSN 1768-3262.