بتا-مانوزیداز

MANBA
معین‌کننده‌ها
نام‌های دیگر	MANBA, MANB1, mannosidase beta
شناسه‌های بیرونی	OMIM: 609489 MGI: 88175 HomoloGene: 4317 GeneCards: MANBA
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[1]
End	135,571,404 bp[1]
هستی‌شناسی ژن
عملکرد ملکولی	• hydrolase activity; • hydrolase activity, hydrolyzing O-glycosyl compounds; • mannose binding; • hydrolase activity, acting on glycosyl bonds; • beta-mannosidase activity;
ترکیبات سلولی	• کافنده‌تن; • lysosomal lumen; • پوسته یاخته; • azurophil granule membrane; • intracellular membrane-bounded organelle;
فرایند زیستی	• دگرگشت; • cellular protein modification process; • oligosaccharide catabolic process; • neutrophil degranulation; • سوخت‌وساز کربوهیدرات; • glycoprotein catabolic process; • mannan catabolic process;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4126
	110173
	ENSG00000109323
	ENSMUSG00000028164
	O00462
	Q8K2I4
	XM_017008203، XM_017008204، XM_017008205، XM_024454048، XM_024454049 NM_005908، XM_017008203، XM_017008204، XM_017008205، XM_024454048، XM_024454049
	XM_006500908، XR_867210 NM_027288، XM_006500908، XR_867210
	XP_016863692، XP_016863693، XP_016863694، XP_024309816، XP_024309817 NP_005899، XP_016863692، XP_016863693، XP_016863694، XP_024309816، XP_024309817
	XP_006500971 NP_081564، XP_006500971
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

بتا-مانوزیداز (انگلیسی: Beta-mannosidase‎) یک آنزیم است که در انسان توسط ژن «MANBA» کُدگذاری می‌شود.[4][5][6][7][8][9]

این آنزیم سبب هیدرولیز ریشه‌های غیراحیاکنندهٔ انتهایی بتا-دی-مانوز در مولکول‌های بتا-دی-مانوزیدها می‌گردد. این آنزیم یکی از اعضای خانوادهٔ بزرگ گلیکوزیل هیدرولیز ۲ محسوب می‌شود و در درون لیزوزوم سلول‌ها جای دارد.

جهش در ژن سازندهٔ این آنزیم سبب بروز نوعی بیماری ذخیرهٔ لیزوزومی به نام «بتا-مانوزیدوزیس» می‌گردد که طیف گسترده‌ای از علائم مغزی-عصبی را شامل می‌شود.[4]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000028164 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: mannosidase".
Chen H, Leipprandt JR, Traviss CE, Sopher BL, Jones MZ, Cavanagh KT, Friderici KH (February 1995). "Molecular cloning and characterization of bovine beta-mannosidase". J. Biol. Chem. 270 (8): 3841–8. doi:10.1074/jbc.270.8.3841. PMID 7876128.
Adams, M.; Richtmyer, N.K.; Hudson, C.S. (1943). "Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases". J. Am. Chem. Soc. 65 (7): 1369–1380. doi:10.1021/ja01247a029.
Bartholomew, B.A.; Perry, A.L. (1973). "The properties of synovial fluid β-mannosidase activity". Biochim. Biophys. Acta. 315 (1): 123–127. doi:10.1016/0005-2744(73)90136-8. PMID 4743897.
Deuel, H.; Lewuenberger, R.; Huber, G. (1950). "Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L". Helv. Chim. Acta. 33 (4): 942–946. doi:10.1002/hlca.19500330424.
Hylin, J.W.; Sawai, K. (1964). "The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase". J. Biol. Chem. 239: 990–992. PMID 14165949.

مشارکت‌کنندگان ویکی‌پدیا. «Beta-mannosidase». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ ژانویه ۲۰۲۱.

برای مطالعهٔ بیشتر

Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.
Kalsi G, Kuo PH, Aliev F, et al. (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
Levade T, Graber D, Flurin V, et al. (1994). "Human beta-mannosidase deficiency associated with peripheral neuropathy". Ann. Neurol. 35 (1): 116–9. doi:10.1002/ana.410350119. PMID 8285582. S2CID 71932852.
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/jvi.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
Sabourdy F, Labauge P, Stensland HM, et al. (2009). "A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant". BMC Med. Genet. 10: 84. doi:10.1186/1471-2350-10-84. PMC 2745377. PMID 19728872.
Hosgood HD, Zhang L, Shen M, et al. (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
Alkhayat AH, Kraemer SA, Leipprandt JR, et al. (1998). "Human beta-mannosidase cDNA characterization and first identification of a mutation associated with human beta-mannosidosis". Hum. Mol. Genet. 7 (1): 75–83. doi:10.1093/hmg/7.1.75. PMID 9384606.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
Gao J, Arbman G, He L, et al. (2008). "MANBA polymorphism was related to increased risk of colorectal cancer in Swedish but not in Chinese populations". Acta Oncol. 47 (3): 372–8. doi:10.1080/02841860701644052. PMID 17899454. S2CID 45674826.
Robinson WE, Montefiori DC, Mitchell WM (1987). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347. PMID 8093218.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211.
Blough HA, Pauwels R, De Clercq E, et al. (1986). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
Hart ML, Saifuddin M, Spear GT (2003). "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin". J. Gen. Virol. 84 (Pt 2): 353–60. doi:10.1099/vir.0.18734-0. PMID 12560567.

پیوند به بیرون

مکان ژنوم MANBA انسانی و صفحهٔ جزئیات ژنی MANBA در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q8K2I4 (Mouse Beta-mannosidase) در PDBe-KB.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000028164 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: mannosidase".

[pmid7876128-5] Chen H, Leipprandt JR, Traviss CE, Sopher BL, Jones MZ, Cavanagh KT, Friderici KH (February 1995). "Molecular cloning and characterization of bovine beta-mannosidase". J. Biol. Chem. 270 (8): 3841–8. doi:10.1074/jbc.270.8.3841. PMID 7876128.

[6] Adams, M.; Richtmyer, N.K.; Hudson, C.S. (1943). "Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases". J. Am. Chem. Soc. 65 (7): 1369–1380. doi:10.1021/ja01247a029.

[7] Bartholomew, B.A.; Perry, A.L. (1973). "The properties of synovial fluid β-mannosidase activity". Biochim. Biophys. Acta. 315 (1): 123–127. doi:10.1016/0005-2744(73)90136-8. PMID 4743897.

[8] Deuel, H.; Lewuenberger, R.; Huber, G. (1950). "Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L". Helv. Chim. Acta. 33 (4): 942–946. doi:10.1002/hlca.19500330424.

[9] Hylin, J.W.; Sawai, K. (1964). "The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase". J. Biol. Chem. 239: 990–992. PMID 14165949.