بتاسلولین
بتاسلولین (انگلیسی: Betacellulin) نام پروتئینی است که در انسان توسط ژن «BTC» کد می‌شود که بر روی بازویِ بلندِ کروموزوم ۴ قرار دارد.[1]
این پروتئین یکی از اعضای خانوادهٔ فاکتورهای رشد اپیدرمی است[1] و به‌صورت یک پیش‌سازِ تراغشایی ساخته می‌شود و سپس توسط فرایندهای پروتئولیتیک به پروتئینی کارآمد مبدل می‌شود.
بتاسلولین یکی از لیگاندهای گیرنده فاکتور رشد اپیدرمی است و دارای ۶۲ تا ۱۱۱ باقیماندهٔ آمینواسیدی است.
منابع
- مشارکت‌کنندگان ویکی‌پدیا. «Betacellulin». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۶ نوامبر ۲۰۱۷.
بیشتر بخوانید
- Kim HS, Shin HS, Kwak HJ, Cho CH, Lee CO, Koh GY (February 2003). "Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase in endothelial cell". FASEB J. 17 (2): 318–20. doi:10.1096/fj.02-0570fje. PMID 12475887.
- Yamamoto T, Akisue T, Marui T, et al. (2004). "Expression of betacellulin, heparin-binding epidermal growth factor and epiregulin in human malignant fibrous histiocytoma". Anticancer Res. 24 (3b): 2007–10. PMID 15274392.
- Nakagawa T, Furuta H, Sanke T, et al. (2005). "Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients". Diabetes Res. Clin. Pract. 68 (3): 188–92. doi:10.1016/j.diabres.2004.09.019. PMID 15936459.
- Silver K, Tolea M, Wang J, et al. (2005). "The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans". Diabetes. 54 (4): 1179–84. doi:10.2337/diabetes.54.4.1179. PMID 15793259.
- Tanimura K, Nakago S, Murakoshi H, et al. (2004). "Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy". Eur. J. Endocrinol. 151 (1): 93–101. doi:10.1530/eje.0.1510093. PMID 15248827.
- Saito T, Okada S, Ohshima K, et al. (2004). "Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF". Endocrinology. 145 (9): 4232–43. doi:10.1210/en.2004-0401. PMID 15192046.
- Elbein SC, Wang X, Karim MA, et al. (2006). "Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects". BMC Med. Genet. 7: 62. doi:10.1186/1471-2350-7-62. PMC 1544326. PMID 16869959.
- Genetos DC, Rao RR, Vidal MA (2010). "Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha". Cell Tissue Res. 340 (1): 81–9. doi:10.1007/s00441-010-0929-0. PMC 2847694. PMID 20165885.
- Moss ML, Bomar M, Liu Q, et al. (2007). "The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events". J. Biol. Chem. 282 (49): 35712–21. doi:10.1074/jbc.M703231200. PMID 17895248.
- Rittié L, Kansra S, Stoll SW, et al. (2007). "Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin". Am. J. Pathol. 170 (6): 2089–99. doi:10.2353/ajpath.2007.060537. PMC 1899432. PMID 17525275.
- Révillion F, Lhotellier V, Hornez L, et al. (2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. 19 (1): 73–80. doi:10.1093/annonc/mdm431. PMID 17962208.
- Silver KD, Shi X, Mitchell BD (2007). "Betacellulin variants and type 2 diabetes in the Old Order Amish". Exp. Clin. Endocrinol. Diabetes. 115 (4): 229–31. doi:10.1055/s-2007-970575. PMID 17479438.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Stoeck A, Shang L, Dempsey PJ (2010). "Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth". J. Cell Sci. 123 (Pt 13): 2319–31. doi:10.1242/jcs.060830. PMC 2886747. PMID 20530572.
- Nagaoka T, Fukuda T, Hashizume T, et al. (2008). "A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1". J. Mol. Biol. 380 (1): 83–94. doi:10.1016/j.jmb.2008.03.054. PMID 18508082.
- Nakano Y, Furuta H, Doi A, et al. (2005). "A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes". Diabetes. 54 (12): 3560–6. doi:10.2337/diabetes.54.12.3560. PMID 16306376.
- Sanderson MP, Erickson SN, Gough PJ, et al. (2005). "ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx". J. Biol. Chem. 280 (3): 1826–37. doi:10.1074/jbc.M408804200. PMID 15507448.
- Dunbar AJ, Goddard C (2000). "Structure-function and biological role of betacellulin". Int. J. Biochem. Cell Biol. 32 (8): 805–15. doi:10.1016/S1357-2725(00)00028-5. PMID 10940639.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Silver KD, Magnuson VL, Tolea M, et al. (2006). "Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations". J. Mol. Med. 84 (7): 616–23. doi:10.1007/s00109-006-0052-6. PMID 16683131.
پیوند به بیرون
- Betacellulin در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
نگارخانه PDB | |
|---|---|
|
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.
