اینتگرین بتا ۴

ITGB4
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QG3, 2YRZ, 3F7P, 3F7Q, 3F7R, 3FQ4, 3FSO, 3H6A, 4Q58, 4WTW, 4WTX
معین‌کننده‌ها
نام‌های دیگر	ITGB4, CD104, GP150, integrin subunit beta 4
شناسه‌های بیرونی	OMIM: 147557 MGI: 96613 HomoloGene: 179 GeneCards: ITGB4
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[1]
End	116,008,412 bp[1]
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948 پیوند پروتئینی; • G protein-coupled receptor binding; • neuregulin binding; • insulin-like growth factor I binding; • integrin binding;
ترکیبات سلولی	• integral component of membrane; • membrane; • receptor complex; • پوسته یاخته; • hemidesmosome; • cell surface; • integrin complex; • پیوند میان‌یاخته‌ای; • cell leading edge; • extracellular exosome; • هسته یاخته; • focal adhesion;
فرایند زیستی	• hemidesmosome assembly; • renal system development; • nail development; • cell motility; • extracellular matrix organization; • خودخواری; • cell communication; • cell adhesion; • response to wounding; • mesodermal cell differentiation; • integrin-mediated signaling pathway; • digestive tract development; • cell-matrix adhesion; • skin development; • amelogenesis; • کوچ یاخته; • cell adhesion mediated by integrin;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3691
	192897
	ENSG00000132470
	ENSMUSG00000020758
	P16144
	A2A863
	NM_000213، NM_001005619، NM_001005731، XM_005257309، XM_005257311، XM_006721866، XM_006721867، XM_006721868، XM_006721870، XM_011524751، NM_001321123 XM_011524752، NM_000213، NM_001005619، NM_001005731، XM_005257309، XM_005257311، XM_006721866، XM_006721867، XM_006721868، XM_006721870، XM_011524751، NM_001321123
	NM_133663، XM_006532572، XM_006532573، XM_006532574، XM_017314349، XM_017314350، XM_017314351 NM_001005608، NM_133663، XM_006532572، XM_006532573، XM_006532574، XM_017314349، XM_017314350، XM_017314351
	NP_001005619، NP_001005731، NP_001308052، XP_005257366، XP_005257368، XP_006721929، XP_006721930، XP_006721931، XP_006721933، XP_011523053، XP_011523054 NP_000204، NP_001005619، NP_001005731، NP_001308052، XP_005257366، XP_005257368، XP_006721929، XP_006721930، XP_006721931، XP_006721933، XP_011523053، XP_011523054
	NP_598424، XP_006532635، XP_006532636، XP_006532637، XP_017169838، XP_017169839، XP_017169840، XP_036012338، XP_036012339، XP_036012340 NP_001005608، NP_598424، XP_006532635، XP_006532636، XP_006532637، XP_017169838، XP_017169839، XP_017169840، XP_036012338، XP_036012339، XP_036012340
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

اینتگرین بتا ۴ (انگلیسی: Integrin beta 4‎) یا CD104، یک پروتئین است که در انسان توسط ژن «ITGB4» کُدگذاری می‌شود.[4]

این پروتئین با پیوند غیر کووالانسی به گیرنده‌های تراغشایی گلیکوپروتئینی اتصال می‌یابند و سیگنال‌های حاصله در بیان ژن‌ها و رشد سلولی نقش دارند.

اینتگرین بتا ۴ به احتمال زیاد نقش بسیار مهمی در زیست‌شناسی سرطان‌های تهاجمی ایفا می‌کند. جهش در ژن ITGB4 سبب بروز بیماری پروانه‌ای به‌همراه بن‌بست پیلور می‌شود.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000020758 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ITGB4 integrin, beta 4".

مشارکت‌کنندگان ویکی‌پدیا. «Integrin beta 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۸ نوامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

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پیوند به بیرون

ITGB4 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020758 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: ITGB4 integrin, beta 4".