OGN

OGN
معین‌کننده‌ها
نام‌های دیگر	OGN, OG, OIF, SLRR3A, osteoglycin
شناسه‌های بیرونی	OMIM: 602383 MGI: 109278 HomoloGene: 8542 GeneCards: OGN
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[1]
End	49,624,501 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948 پیوند پروتئینی; • growth factor activity; • extracellular matrix structural constituent conferring compression resistance;
ترکیبات سلولی	• extracellular vesicle; • GO:0005578 بافت‌مانه برون‌یاخته‌ای; • lysosomal lumen; • Golgi lumen; • extracellular exosome; • extracellular space; • extracellular region; • collagen-containing extracellular matrix;
فرایند زیستی	• negative regulation of smooth muscle cell proliferation; • axonogenesis; • keratan sulfate catabolic process; • keratan sulfate biosynthetic process; • regulation of signaling receptor activity; • ورارسانی پیام;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4969
	18295
	ENSG00000106809
	ENSMUSG00000021390
	P20774
	Q62000
	NM_014057، NM_024416 NM_033014، NM_014057، NM_024416
	NM_008760
	NP_077727، NP_148935 NP_054776، NP_077727، NP_148935; NP_148935.1 NP_054776.1، NP_148935.1
	NP_032786
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

اُستئوگلیسین (انگلیسی: Osteoglycin‎) که با نام «میمیکَن» هم شناخته می‌شود، نام پروتئینی است که در انسان توسط ژن «OGN» کُد می‌شود.[4]

این پروتئین در کنار TGF-β موجب استخوان‌سازی نابجا در بافت‌های دیگر می‌شود.

میزان بیان ژنی این پروتئین، با بروز کاردیومگالی و به‌ویژه هیپرتروفی بطن چپ در ارتباط است.[5][6]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000021390 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: OGN osteoglycin".
"Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.
Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592.

مشارکت‌کنندگان ویکی‌پدیا. «OGN (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۲ دسامبر ۲۰۱۷.

بیشتر بخوانید

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Madisen L, Neubauer M, Plowman G, et al. (1990). "Molecular cloning of a novel bone-forming compound: osteoinductive factor". DNA Cell Biol. 9 (5): 303–9. doi:10.1089/dna.1990.9.303. PMID 2372374.
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Matsushima N, Ohyanagi T, Tanaka T, Kretsinger RH (2000). "Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins. 38 (2): 210–25. doi:10.1002/(SICI)1097-0134(20000201)38:2<210::AID-PROT9>3.0.CO;2-1. PMID 10656267.
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Tasheva ES, Pettenati M, Von Kap-Her C, Conrad GW (2000). "Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 326–7. doi:10.1159/000015521. PMID 10828622.
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Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tasheva ES, Conrad GW (2003). "The UV responsive elements in the human mimecan promoter: a functional characterization". Mol. Vis. 9: 1–9. PMID 12533723.
Luijendijk MW, van de Pol TJ, van Duijnhoven G, et al. (2004). "Cloning, characterization, and mRNA expression analysis of novel human fetal cochlear cDNAs". Genomics. 82 (4): 480–90. doi:10.1016/S0888-7543(03)00150-2. PMID 13679028.
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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Hu SM, Li F, Yu HM, et al. (2006). "The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor-1 as a marker for diagnosing pituitary tumors". J. Clin. Endocrinol. Metab. 90 (12): 6657–64. doi:10.1210/jc.2005-0322. PMID 16189248.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000021390 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: OGN osteoglycin".

[urlBBC_NEWS_|_Health_|_Big_hearts_have_genetic_problem-5] "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.

[pmid18443592-6] Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592.