GRB2

GRB2
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW
معین‌کننده‌ها
نام‌های دیگر	GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
شناسه‌های بیرونی	OMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[1]
End	115,708,597 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein domain specific binding; • SH3 domain binding; • protein kinase binding; • identical protein binding; • neurotrophin TRKA receptor binding; • protein phosphatase binding; • GO:0001948 پیوند پروتئینی; • ephrin receptor binding; • insulin receptor substrate binding; • epidermal growth factor receptor binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphoprotein binding; • enzyme binding; • RNA binding; • non-membrane spanning protein tyrosine kinase activity; • phosphotyrosine residue binding;
ترکیبات سلولی	• extracellular exosome; • هستک; • سیتوپلاسم; • نوکلئوپلاسم; • COP9 signalosome; • دستگاه گلژی; • سیتوزول; • هسته یاخته; • cell-cell junction; • membrane; • Grb2-EGFR complex; • اندوزوم; • vesicle membrane; • پوسته یاخته; • extrinsic component of cytoplasmic side of plasma membrane; • protein-containing complex; • intracellular anatomical structure;
فرایند زیستی	• T cell costimulation; • Fc-gamma receptor signaling pathway involved in phagocytosis; • branching involved in labyrinthine layer morphogenesis; • MAPK cascade; • epidermal growth factor receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • insulin receptor signaling pathway; • receptor internalization; • cell-cell signaling; • axon guidance; • positive regulation of reactive oxygen species metabolic process; • cellular response to ionizing radiation; • Fc-epsilon receptor signaling pathway; • GO:0022415 viral process; • positive regulation of actin filament polymerization; • signal transduction in response to DNA damage; • negative regulation of epidermal growth factor receptor signaling pathway; • leukocyte migration; • regulation of MAPK cascade; • anatomical structure formation involved in morphogenesis; • پیرش; • ERBB2 signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • protein heterooligomerization; • entry of bacterium into host cell; • membrane organization; • کوچ یاخته; • دگرگونی یاخته‌; • peptidyl-tyrosine autophosphorylation; • regulation of cell population proliferation; • دستگاه ایمنی ذاتی; • Ras protein signal transduction; • interleukin-15-mediated signaling pathway; • positive regulation of protein kinase B signaling; • regulation of molecular function; • cytokine-mediated signaling pathway; • positive regulation of Ras protein signal transduction; • neurotrophin TRK receptor signaling pathway;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2885
	14784
	ENSG00000177885
	ENSMUSG00000059923
	P62993
	Q60631
	NM_002086 NM_203506، NM_002086
	NM_001313936، NM_001313937 NM_008163، NM_001313936، NM_001313937
	NP_987102 NP_002077، NP_987102
	NP_001300866، NP_032189 NP_001300865، NP_001300866، NP_032189
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین شمارهٔ ۲ متصل به گیرندهٔ فاکتور رشد (انگلیسی: Growth factor receptor-bound protein 2‎) که به‌اختصار «Grb2» نامیده می‌شود، یک پروتئین وفق‌دهنده ترارسانی پیام است که در فرایند ترارسانی پیام/ارتباطات سلولی دخالت دارد. در انسان، این پروتئین توسط ژن «GRB2» کدگذاری می‌شود.[4][5]

پروتئینی که توسط ژن «GRB2» ساخته می‌شود به گیرنده‌هایی چون گیرنده فاکتور رشد اپیدرمی اتصال می‌یابد.

تخریب این ژن در موش‌های آزمایشگاهی باعث شد تا رویان آنها در مراحل اولیهٔ تشکیل از بین بروند.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000059923 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Matuoka K, Shibata M, Yamakawa A, Takenawa T (Oct 1992). "Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9015–9. doi:10.1073/pnas.89.19.9015. PMC 50055. PMID 1384039.
Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (Aug 1992). "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling". Cell. 70 (3): 431–42. doi:10.1016/0092-8674(92)90167-B. PMID 1322798.

مشارکت‌کنندگان ویکی‌پدیا. «GRB2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۱ ژانویه ۲۰۱۸.

بیشتر بخوانید

Colledge M, Froehner SC (May 1998). "Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction". Annals of the New York Academy of Sciences. 841: 17–27. doi:10.1111/j.1749-6632.1998.tb10907.x. PMID 9668219.
Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (Jan 1999). "Waltzing with WASP". Trends in Cell Biology. 9 (1): 15–9. doi:10.1016/S0962-8924(98)01411-1. PMID 10087612.
O'Sullivan E, Kinnon C, Brickell P (1999). "Wiskott-Aldrich syndrome protein, WASP". The International Journal of Biochemistry & Cell Biology. 31 (3–4): 383–7. doi:10.1016/S1357-2725(98)00118-6. PMID 10224664.
Schlaepfer DD, Hauck CR, Sieg DJ (1999). "Signaling through focal adhesion kinase". Progress in Biophysics and Molecular Biology. 71 (3–4): 435–78. doi:10.1016/S0079-6107(98)00052-2. PMID 10354709.
Vidal M, Liu WQ, Gril B, Assayag F, Poupon MF, Garbay C (2004). "[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]". Journal De La Société De Biologie. 198 (2): 133–7. PMID 15368963.

پیوند به بیرون

GRB2 Adaptor Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000059923 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_1384039-4] Matuoka K, Shibata M, Yamakawa A, Takenawa T (Oct 1992). "Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9015–9. doi:10.1073/pnas.89.19.9015. PMC 50055. PMID 1384039.

[pmid_1322798-5] Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (Aug 1992). "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling". Cell. 70 (3): 431–42. doi:10.1016/0092-8674(92)90167-B. PMID 1322798.