لیگاند فاس

FASLG
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MSV
معین‌کننده‌ها
نام‌های دیگر	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand
شناسه‌های بیرونی	OMIM: 134638 MGI: 99255 HomoloGene: 533 GeneCards: FASLG
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[1]
End	161,788,495 bp[1]
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• cytokine activity; • GO:0001948 پیوند پروتئینی; • tumor necrosis factor receptor binding; • signaling receptor binding; • death receptor binding;
ترکیبات سلولی	• integral component of membrane; • membrane; • cytoplasmic vesicle lumen; • پوسته یاخته; • integral component of plasma membrane; • cell surface; • lysosomal lumen; • حفره غشایی; • perinuclear region of cytoplasm; • لیپید رفت; • کافنده‌تن; • extracellular exosome; • GO:0016023 cytoplasmic vesicle; • هسته یاخته; • external side of plasma membrane; • extracellular region; • extracellular space;
فرایند زیستی	• T cell apoptotic process; • regulation of transcription, DNA-templated; • cell-cell signaling; • endosomal lumen acidification; • negative regulation of transcription by RNA polymerase II; • retinal cell programmed cell death; • transcription, DNA-templated; • response to lipopolysaccharide; • positive regulation of neuron apoptotic process; • positive regulation of endothelial cell apoptotic process; • necroptotic signaling pathway; • immune response; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of angiogenesis; • regulation of extrinsic apoptotic signaling pathway via death domain receptors; • cellular chloride ion homeostasis; • response to growth factor; • inflammatory cell apoptotic process; • positive regulation of epidermal growth factor receptor signaling pathway; • extrinsic apoptotic signaling pathway via death domain receptors; • ورارسانی پیام; • extrinsic apoptotic signaling pathway; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • GO:0060554، GO:0060555 نکروپتوز; • apoptotic signaling pathway; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • مرگ برنامه‌ریزی‌شده یاخته; • release of sequestered calcium ion into cytosol by endoplasmic reticulum; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	356
	14103
	ENSG00000117560
	ENSMUSG00000000817
	P48023
	P41047
	NM_000639 NM_001302746، NM_000639
	NM_010177 NM_001205243، NM_010177
	NP_001289675 NP_000630، NP_001289675
	NP_034307 NP_001192172، NP_034307
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

لیگاند فاس (FasL یا CD95L) که با نام «CD178» هم شناخته می‌شود، نوعی پروتئین تراپوسته‌ای مربوط به عامل نکروز تومور است. اتصال آن با گیرندهٔ ویژهٔ خود، موجب آپوپتوز می‌شود.این لیگاند نقش مهمی را در تنظیم سیستم ایمنی بدن و سرطان ایفا می‌کند.[4]

پانویس

GRCm38: Ensembl release 89: ENSMUSG00000000817 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
https://www.ncbi.nlm.nih.gov/pubmed?linkname=gene_pubmed&from_uid=356

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000000817 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] ttps://www.ncbi.nlm.nih.gov/pubmed?linkname=gene_pubmed&from_uid=356